9H-fluoren-9-ylmethyl[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]carbamate

Base Information

Chemical Name:9H-fluoren-9-ylmethyl[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]carbamate
CAS No.:1425947-57-4
Molecular Formula:C₃₆H₃₃FN₂O₄S
Molecular Weight:608.733
Hs Code.:

Synonyms:9H-fluoren-9-ylmethyl[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]carbamate

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Chemical Property of 9H-fluoren-9-ylmethyl[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]carbamate

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Technology Process of 9H-fluoren-9-ylmethyl[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]carbamate

There total 1 articles about 9H-fluoren-9-ylmethyl[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425947-56-3
(9H-fluoren-9-yl)methyl {(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2-fluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl}carbamothioyl carbamate

: 1425947-57-4
9H-fluoren-9-ylmethyl[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]carbamate

Guidance literature:: With hydrogenchloride; In methanol; water; at 70 ℃; for 2h;

Reference yield: 88.0%

: 1425947-57-4
9H-fluoren-9-ylmethyl[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]carbamate

: 1220329-04-3
[(4aR,6R,8aS)-2-amino-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-6-yl]methanol

Guidance literature:: 9H-fluoren-9-ylmethyl[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]carbamate; With hydrogenchloride; water;

With piperidine; In acetonitrile; at 20 ℃; for 42h;