5-(N-9-fluorenylmethoxycarbonylallylamido)-5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-2'-deoxyuridine

Base Information

Chemical Name:5-(N-9-fluorenylmethoxycarbonylallylamido)-5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-2'-deoxyuridine
CAS No.:1417629-78-7
Molecular Formula:C₅₀H₄₇N₃O₁₀
Molecular Weight:849.937
Hs Code.:

Synonyms:5-(N-9-fluorenylmethoxycarbonylallylamido)-5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-2'-deoxyuridine

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Chemical Property of 5-(N-9-fluorenylmethoxycarbonylallylamido)-5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-2'-deoxyuridine

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Technology Process of 5-(N-9-fluorenylmethoxycarbonylallylamido)-5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-2'-deoxyuridine

There total 5 articles about 5-(N-9-fluorenylmethoxycarbonylallylamido)-5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54-42-2,162239-35-2
5-Iodo-2'-deoxyuridine

: 1417629-78-7
5-(N-9-fluorenylmethoxycarbonylallylamido)-5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrachloropalladate(II) / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

2: ammonium hydroxide / 5 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: pyridine / 20 °C / Inert atmosphere

5: 5 h / 20 °C / Inert atmosphere

With pyridine; ammonium hydroxide; sodium tetrachloropalladate(II); N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201201662 DOI:10.1002/chem.201201662

Reference yield:

: 96102-22-6
5-(3'-trifluoroacetamidoallyl)-2'-deoxyuridine

: 1417629-78-7
5-(N-9-fluorenylmethoxycarbonylallylamido)-5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium hydroxide / 5 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: pyridine / 20 °C / Inert atmosphere

4: 5 h / 20 °C / Inert atmosphere

With pyridine; ammonium hydroxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water;
DOI:10.1002/chem.201201662 DOI:10.1002/chem.201201662

Reference yield:

: 143908-73-0
C₁₂H₁₇N₃O₅

: 1417629-78-7
5-(N-9-fluorenylmethoxycarbonylallylamido)-5'-O-(4,4'-dimethoxytrityl)-3'-O-acetyl-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / water; tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: pyridine / 20 °C / Inert atmosphere

3: 5 h / 20 °C / Inert atmosphere

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water;
DOI:10.1002/chem.201201662 DOI:10.1002/chem.201201662