3-hydroxyproquazone

Base Information

• Chemical Name: 3-hydroxyproquazone
• CAS No.: 65765-07-3
• Molecular Formula: C19H20N2O2
• Molecular Weight: 294.352
• Mol file: 65765-07-3.mol

Synonyms:LS-7286;4-(3-hydroxy-phenyl)-1-isopropyl-7-methyl-1H-quinazolin-2-one;meta-Hydroxyproquazone;4-(3-hydroxyphenyl)-7-methyl-1-(propan-2-yl)quinazolin-2(1H)-one;Compound 50-892;1-isopropyl-4-(3-hydroxyphenyl)-7-methyl-2(1H)-quinazolinone;3-Hydroxyproquazone;2(1H)-Quinazolinone,4-(3-hydroxyphenyl)-7-methyl-1-(1-methylethyl);m-hydroxyproquazone;4-(3-Hydroxyphenyl)-7-methyl-1-(1-methylethyl)-2(1H)-quinazolinone;

Chemical Property of 3-hydroxyproquazone

Chemical Property:

• Vapor Pressure: 1.36E-10mmHg at 25°C
• Boiling Point: 499.3°C at 760 mmHg
• Flash Point: 255.8°C
• PSA: 55.12000
• Density: 1.2g/cm³
• LogP: 3.65840

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-hydroxyproquazone

There total 3 articles about 3-hydroxyproquazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-isopropyl-4-(3-methoxy-phenyl)-7-methyl-1H-quinazolin-2-one (65765-06-2) + butan-1-ol (71-36-3) → m-hydroxyproquazone (65765-07-3)

Guidance literature:

With hydrogen bromide; In water;

Reference yield:

1-isopropyl-4-(3-methoxy-phenyl)-7-methyl-3,4-dihydro-1H-quinazolin-2-one (65765-05-1) → m-hydroxyproquazone (65765-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate; formaldehyd / 1,4-dioxane; water; benzene

2: hydrogen bromide / water

With potassium permanganate; formaldehyd; hydrogen bromide; In 1,4-dioxane; water; benzene;

Reference yield:

→ m-hydroxyproquazone (65765-07-3)

Guidance literature:

upstream raw materials:

1-isopropyl-4-(3-methoxy-phenyl)-7-methyl-1H-quinazolin-2-one

butan-1-ol

1-isopropyl-4-(3-methoxy-phenyl)-7-methyl-3,4-dihydro-1H-quinazolin-2-one

Downstream raw materials:

1-Isopropyl-4-(3-acetoxyphenyl)-7-methyl-2(1H)-quinazolinone

Refernces

• 1、 -. "Hydroxymethyl-substituted-2(1H)-quinazolinones". . . Retrieved 2008/06/13.