Technology Process of 5-(methylamino)-2-[[(2S,3R,5R,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid
There total 55 articles about 5-(methylamino)-2-[[(2S,3R,5R,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Li(1+)*C9H21S(1-);
In
N,N,N,N,N,N-hexamethylphosphoric triamide;
for 3.5h;
Ambient temperature;
- Guidance literature:
-
With
lithium n-propylmercaptide;
In
N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ja00516a069
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) (C6H11)2NMgBr / 1.) THF, -50 deg C, 2.) 0 deg C
2: 1.) NaOMe, 2.) Zn/AcOH, conc. HCl / 1.) CH2Cl2, MeOH, room temperature 2.) THF, room temperature
3: LiSPr / hexamethylphosphoric acid triamide / Ambient temperature
With
hydrogenchloride; bis(cyclohexyl)aminomagnesium bromide; sodium methylate; lithium n-propylmercaptide; acetic acid; zinc;
In
N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4039(00)95911-2
