methyl 4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]pyrazin-5-yl]benzoate

Base Information

Chemical Name:methyl 4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]pyrazin-5-yl]benzoate
CAS No.:919787-07-8
Molecular Formula:C₂₂H₂₀N₄O₂
Molecular Weight:372.426
Hs Code.:

Synonyms:methyl 4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]pyrazin-5-yl]benzoate

Suppliers and Price of methyl 4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]pyrazin-5-yl]benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]pyrazin-5-yl]benzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]pyrazin-5-yl]benzoate

There total 4 articles about methyl 4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]pyrazin-5-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 849200-67-5
N-(5-bromoimidazo[1,5-a]pyrazin-8-yl)-2,6-dimethylphenylamine

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 919787-07-8
methyl 4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]pyrazin-5-yl]benzoate

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; toluene; at 90 ℃; for 15h;
DOI:10.1016/j.bmc.2006.10.041

Reference yield:

: 849200-66-4
5-bromoimidazo[1,5-a]pyrazin-8(7H)-one

: 919787-07-8
methyl 4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]pyrazin-5-yl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus oxychloride; DMF / Heating

2: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 2 h / 60 °C

3: 56 percent / potassium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride / dimethylformamide; toluene; H₂O / 15 h / 90 °C

With sodium hexamethyldisilazane; potassium carbonate; N,N-dimethyl-formamide; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; 3: Suzuki coupling;
DOI:10.1016/j.bmc.2006.10.041

Reference yield:

: 5-bromo-8-chloroimidazo[1,5-a]pyrazine

: 919787-07-8
methyl 4-[8-(2,6-dimethylphenylamino)imidazo[1,5-a]pyrazin-5-yl]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 2 h / 60 °C

2: 56 percent / potassium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride / dimethylformamide; toluene; H₂O / 15 h / 90 °C

With sodium hexamethyldisilazane; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.10.041