(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2R,3R)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

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Chemical Name:(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2R,3R)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
CAS No.:100938-15-6
Molecular Formula:C₃₁H₂₇ClN₂O₆S₂
Molecular Weight:623.15
Hs Code.:

(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2R,3R)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Synonyms:(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2R,3R)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

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Chemical Property of (S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2R,3R)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

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Technology Process of (S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2R,3R)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

There total 6 articles about (S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2R,3R)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.9%

: 91872-31-0
(S)-1-(2-naphthyl-sulfonyl)pyrrolidine-2-carbonyl chloride

: 100902-58-7
(+/-)-cis-9-chloro-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

: 100938-15-6
(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2R,3R)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

: 100902-59-8
(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2S,3S)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Guidance literature:: With pyridine; for 18h; Ambient temperature;
DOI:10.1021/jm00106a032

Reference yield:

: 14371-77-8
6-chloro-2-nitrothiophenol

: 100938-15-6
(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2R,3R)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 76.7 percent / Zn(OAc)2*2H₂O / toluene / 3 h / Ambient temperature

2: 90.2 percent / H₂, AcOH / 10percent Pd/C / ethanol / 11 h / Ambient temperature

3: 48.5 percent / NaH, DMSO / 0.08 h / Ambient temperature

4: 39.3 percent / pyridine / 18 h / Ambient temperature

With pyridine; zinc diacetate; hydrogen; sodium hydride; acetic acid; dimethyl sulfoxide; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00106a032

Reference yield:

: 96125-49-4
methyl trans-3-(4-methoxyphenyl)glycidate

: 100938-15-6
(S)-1-(Naphthalene-2-sulfonyl)-pyrrolidine-2-carboxylic acid (2R,3R)-9-chloro-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 76.7 percent / Zn(OAc)2*2H₂O / toluene / 3 h / Ambient temperature

2: 90.2 percent / H₂, AcOH / 10percent Pd/C / ethanol / 11 h / Ambient temperature

3: 48.5 percent / NaH, DMSO / 0.08 h / Ambient temperature

4: 39.3 percent / pyridine / 18 h / Ambient temperature

With pyridine; zinc diacetate; hydrogen; sodium hydride; acetic acid; dimethyl sulfoxide; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00106a032