2-Methyl-N-(2-(4-morpholinyl)ethyl)-4-(3-nitrophenyl)-6-phenylnicotinamide

Base Information

Chemical Name:2-Methyl-N-(2-(4-morpholinyl)ethyl)-4-(3-nitrophenyl)-6-phenylnicotinamide
CAS No.:113243-75-7
Molecular Formula:C₂₅H₂₆N₄O₄
Molecular Weight:446.506
Hs Code.:
DSSTox Substance ID:DTXSID70150329
Nikkaji Number:J523.913C
Wikidata:Q83016380

Synonyms:2-methyl-N-(2-(4-morpholinyl)ethyl)-4-(3-nitrophenyl)-6-phenylnicotinamide;FR 76830;FR 76830, dihydrochloride;FR 76830, monohydrochloride;FR-76830

Suppliers and Price of 2-Methyl-N-(2-(4-morpholinyl)ethyl)-4-(3-nitrophenyl)-6-phenylnicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-Methyl-N-(2-(4-morpholinyl)ethyl)-4-(3-nitrophenyl)-6-phenylnicotinamide

Chemical Property:

Vapor Pressure:5.71E-14mmHg at 25°C
Boiling Point:591.6°C at 760 mmHg
Flash Point:311.6°C
Density:1.23g/cm³
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:446.19540532
Heavy Atom Count:33
Complexity:645

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=CC(=N1)C2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)NCCN4CCOCC4

Technology Process of 2-Methyl-N-(2-(4-morpholinyl)ethyl)-4-(3-nitrophenyl)-6-phenylnicotinamide

There total 8 articles about 2-Methyl-N-(2-(4-morpholinyl)ethyl)-4-(3-nitrophenyl)-6-phenylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.6%

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 122274-57-1
N-(2-morpholinoethyl)acetoacetamide

: 123819-45-4
1,4-dihydro-3-(2-morpholinoethylcarbamoyl)-2-methyl-4-(3-nitrophenyl)-6-phenylpyridine

: 614-48-2,24721-24-2
(E)-3-nitrochalcone

: 113243-75-7
3-(2-Morpholinoethylcarbamoyl)-2-methyl-4-(3-nitrophenyl)-6-phenylpyridine

Guidance literature:: With ammonium acetate; manganese dioxide; In tetrahydrofuran; water; ethyl acetate; 4-methyl-2-pentanone;

Reference yield: 31.2%

: N-(2-morpholinoethyl)-3-aminocrotonamide

: 614-48-2,24721-24-2
(E)-3-nitrochalcone

: 113243-75-7
3-(2-Morpholinoethylcarbamoyl)-2-methyl-4-(3-nitrophenyl)-6-phenylpyridine

Guidance literature:: In toluene;

Reference yield:

: 614-48-2,24721-24-2
3-nitrochalcone

: 113243-75-7
3-(2-Morpholinoethylcarbamoyl)-2-methyl-4-(3-nitrophenyl)-6-phenylpyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 20.8 percent / butan-1-ol / 6 h / Heating

2: 50.3 percent / MnO₂ / CHCl₃ / 1 h / Heating

3: 46.6 percent / aq. KOH / ethanol / 6 h / Heating

4: SOCl₂ / CH₂Cl₂; dimethylformamide / 2.5 h / 7 °C

5: CH₂Cl₂; dimethylformamide / 2 h / 7 °C

With manganese(IV) oxide; potassium hydroxide; thionyl chloride; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1248/cpb.41.156