(3aS,3bR,6S,6aS,7aR)-6-(2-Hydroxy-cyclopentyl)-2,2-dimethyl-hexahydro-1,3-dioxa-4-aza-cyclopenta[a]pentalene-4-carboxylic acid benzyl ester

Base Information

Chemical Name:(3aS,3bR,6S,6aS,7aR)-6-(2-Hydroxy-cyclopentyl)-2,2-dimethyl-hexahydro-1,3-dioxa-4-aza-cyclopenta[a]pentalene-4-carboxylic acid benzyl ester
CAS No.:359436-40-1
Molecular Formula:C₂₃H₃₁NO₅
Molecular Weight:401.503
Hs Code.:

Synonyms:(3aS,3bR,6S,6aS,7aR)-6-(2-Hydroxy-cyclopentyl)-2,2-dimethyl-hexahydro-1,3-dioxa-4-aza-cyclopenta[a]pentalene-4-carboxylic acid benzyl ester

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Chemical Property of (3aS,3bR,6S,6aS,7aR)-6-(2-Hydroxy-cyclopentyl)-2,2-dimethyl-hexahydro-1,3-dioxa-4-aza-cyclopenta[a]pentalene-4-carboxylic acid benzyl ester

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Technology Process of (3aS,3bR,6S,6aS,7aR)-6-(2-Hydroxy-cyclopentyl)-2,2-dimethyl-hexahydro-1,3-dioxa-4-aza-cyclopenta[a]pentalene-4-carboxylic acid benzyl ester

There total 10 articles about (3aS,3bR,6S,6aS,7aR)-6-(2-Hydroxy-cyclopentyl)-2,2-dimethyl-hexahydro-1,3-dioxa-4-aza-cyclopenta[a]pentalene-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 359436-39-8
(3aS,3bR,6S,6aS,7aR)-6-Cyclopent-1-enyl-2,2-dimethyl-hexahydro-1,3-dioxa-4-aza-cyclopenta[a]pentalene-4-carboxylic acid benzyl ester

: 359436-40-1
(3aS,3bR,6S,6aS,7aR)-6-(2-Hydroxy-cyclopentyl)-2,2-dimethyl-hexahydro-1,3-dioxa-4-aza-cyclopenta[a]pentalene-4-carboxylic acid benzyl ester

Guidance literature:: (3aS,3bR,6S,6aS,7aR)-6-Cyclopent-1-enyl-2,2-dimethyl-hexahydro-1,3-dioxa-4-aza-cyclopenta[a]pentalene-4-carboxylic acid benzyl ester; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 ℃;

With sodium hydroxide; water; dihydrogen peroxide;
DOI:10.1016/S0040-4039(01)00782-1

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 359436-40-1
(3aS,3bR,6S,6aS,7aR)-6-(2-Hydroxy-cyclopentyl)-2,2-dimethyl-hexahydro-1,3-dioxa-4-aza-cyclopenta[a]pentalene-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃ / diethyl ether

2.1: 71 percent / NaH; NaI / tetrahydrofuran

3.1: Ph₂O / 280 °C

4.1: BH₃*Me₂S / tetrahydrofuran / 0 °C

4.2: 89 percent / H₂O₂; NaOH; water

With diphenylether; dimethylsulfide borane complex; sodium hydride; potassium carbonate; sodium iodide; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4039(01)00782-1

Reference yield:

: 133693-88-6
(2-chloroethylidene)cyclopentane

: 359436-40-1
(3aS,3bR,6S,6aS,7aR)-6-(2-Hydroxy-cyclopentyl)-2,2-dimethyl-hexahydro-1,3-dioxa-4-aza-cyclopenta[a]pentalene-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / NaH; NaI / tetrahydrofuran

2.1: 95 percent / TBAF / tetrahydrofuran

3.1: 98 percent / NaH / tetrahydrofuran / -30 - 0 °C

4.1: Ph₂O / 280 °C

5.1: BH₃*Me₂S / tetrahydrofuran / 0 °C

5.2: 89 percent / H₂O₂; NaOH; water

With diphenylether; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; sodium hydride; sodium iodide; In tetrahydrofuran;
DOI:10.1016/S0040-4039(01)00782-1