(E)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

Base Information

• Chemical Name: (E)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene
• CAS No.: 1430119-03-1
• Molecular Formula: C₁₆H₁₃F₃
• Molecular Weight: 262.274
• Mol file: 1430119-03-1.mol

Synonyms:(E)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

Chemical Property of (E)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

Chemical Property:

Purity/Quality:

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Technology Process of (E)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

There total 7 articles about (E)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

1-(p-methylphenyl)-3,3,3-trifluoropropyne (82203-82-5) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → (E)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene (1430119-03-1) + (Z)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

Guidance literature:

With acetonitrile; at 20 ℃; for 0.5h; Reagent/catalyst;

DOI:10.1134/S1070428013030032

Reference yield: 25.0%

1-(p-methylphenyl)-3,3,3-trifluoropropyne (82203-82-5) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → (E)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene (1430119-03-1) + 3,3,3-trifluoro-1-(4-methylphenyl)-1-phenylpropan-1-ol (1430119-30-4) + (Z)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

Guidance literature:

1-(p-methylphenyl)-3,3,3-trifluoropropyne; benzene; With trifluorormethanesulfonic acid; at 20 ℃; for 0.5h;

With water;

DOI:10.1134/S1070428013030032

Reference yield:

2-bromo-1,1,1-trifluoro-3-(4-methoxyphenyl)-3-phenylpropane → (E)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene (1430119-03-1) + (Z)-1-methyl-4-(3,3,3-trifluoro-1-phenylprop-1-en-1-yl)benzene

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 20h; Overall yield = 87 %;

DOI:10.1016/j.tetlet.2016.01.099

upstream raw materials:

1-(p-methylphenyl)-3,3,3-trifluoropropyne

benzene

4-Methylbenzophenone

1-phenyl-1-p-tolyl-ethylene