2-{[3-ethoxycarbonyl-5-(2-methoxy-phenyl)-4-methyl-thiophen-2-ylamino]-methylene}-malonic acid diethyl ester

Base Information

• Chemical Name: 2-{[3-ethoxycarbonyl-5-(2-methoxy-phenyl)-4-methyl-thiophen-2-ylamino]-methylene}-malonic acid diethyl ester
• CAS No.: 174072-72-1
• Molecular Formula: C₂₃H₂₇NO₇S
• Molecular Weight: 461.536
• Mol file: 174072-72-1.mol

Synonyms:2-{[3-ethoxycarbonyl-5-(2-methoxy-phenyl)-4-methyl-thiophen-2-ylamino]-methylene}-malonic acid diethyl ester

Chemical Property of 2-{[3-ethoxycarbonyl-5-(2-methoxy-phenyl)-4-methyl-thiophen-2-ylamino]-methylene}-malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[3-ethoxycarbonyl-5-(2-methoxy-phenyl)-4-methyl-thiophen-2-ylamino]-methylene}-malonic acid diethyl ester

There total 1 articles about 2-{[3-ethoxycarbonyl-5-(2-methoxy-phenyl)-4-methyl-thiophen-2-ylamino]-methylene}-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl 2-ethoxymethylenemalonate (87-13-8) + 2-amino-5-(2-methoxy-phenyl)-4-methyl-thiophene-3-carboxylic acid ethyl ester (174072-71-0) → 2-{[3-ethoxycarbonyl-5-(2-methoxy-phenyl)-4-methyl-thiophen-2-ylamino]-methylene}-malonic acid diethyl ester (174072-72-1)

Guidance literature:

at 120 ℃;

DOI:10.1021/jm0512894

Reference yield:

2-{[3-ethoxycarbonyl-5-(2-methoxy-phenyl)-4-methyl-thiophen-2-ylamino]-methylene}-malonic acid diethyl ester (174072-72-1) → ethyl N-[3-carboxy-5-(2-methoxyphenyl)-4-methyl-2-thienyl]aminomethylenemalonate (174072-76-5)

Guidance literature:

With potassium hydroxide; In 1,4-dioxane; ethanol; at 70 ℃;

DOI:10.1021/jm0512894

Reference yield:

2-{[3-ethoxycarbonyl-5-(2-methoxy-phenyl)-4-methyl-thiophen-2-ylamino]-methylene}-malonic acid diethyl ester (174072-72-1) → ethyl 4-hydroxy-2-(2-methoxyphenyl)-3-methylthieno[2,3-b]pyridine-5-carboxylate (174072-81-2)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethanol; dioxane / 70 °C

2: 73 percent / polyphosphate ester / 120 °C

With potassium hydroxide; polyphosphate ester; In 1,4-dioxane; ethanol;

DOI:10.1021/jm0512894

upstream raw materials:

diethyl 2-ethoxymethylenemalonate

2-amino-5-(2-methoxy-phenyl)-4-methyl-thiophene-3-carboxylic acid ethyl ester

Downstream raw materials:

ethyl N-[3-carboxy-5-(2-methoxyphenyl)-4-methyl-2-thienyl]aminomethylenemalonate

ethyl 4-hydroxy-2-(2-methoxyphenyl)-3-methylthieno[2,3-b]pyridine-5-carboxylate

ethyl 4,7-dihydro-7-(2-methoxybenzyl)-2-(2-methoxyphenyl)-3-methyl-4-oxothieno[2,3-b]pyridine-5-carboxylate

3-bromomethyl-7-(2-methoxy-benzyl)-2-(2-methoxy-phenyl)-4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester