Adenosine, 4'-azido-2'-deoxy-

Base Information

Chemical Name:Adenosine, 4'-azido-2'-deoxy-
CAS No.:130108-73-5
Molecular Formula:C₁₀H₁₂N₈O₃
Molecular Weight:292.257
Hs Code.:
DSSTox Substance ID:DTXSID70156341
Nikkaji Number:J481.000G
Wikidata:Q83024389
ChEMBL ID:CHEMBL3143914
Mol file:130108-73-5.mol

Synonyms:4'-Azido-2'-deoxyadenosine;Adenosine, 4'-azido-2'-deoxy-;4'-AzdA;130108-73-5;CHEMBL3143914;SCHEMBL15643110;DTXSID70156341;A901701;(2R,3S,5R)-5-(6-aminopurin-9-yl)-2-azido-2-(hydroxymethyl)tetrahydrofuran-3-ol;2-amino-9-((2R,4S,5R)-5-azido-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-3H-purin-6(9H)-one

Suppliers and Price of Adenosine, 4'-azido-2'-deoxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Adenosine, 4'-azido-2'-deoxy-

Chemical Property:

PSA：169.06000
LogP:-0.27884
XLogP3:0.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:3
Exact Mass:292.10323627
Heavy Atom Count:21
Complexity:446

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(OC1N2C=NC3=C(N=CN=C32)N)(CO)N=[N+]=[N-])O
Isomeric SMILES:C1[C@@H]([C@](O[C@H]1N2C=NC3=C(N=CN=C32)N)(CO)N=[N+]=[N-])O

Technology Process of Adenosine, 4'-azido-2'-deoxy-

There total 6 articles about Adenosine, 4'-azido-2'-deoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59676-20-9
9-(2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)adenine

: 130108-73-5
4'-azido-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: iodine monochloride, sodium azide / dimethylformamide / 1 h / Ambient temperature

2: DAMP, pyridine

3: 1.) m-chloroperbenzoic acid, water, 2.) sodium methoxide / 1.) dichloromethane, RT, 3.5 h, 2.) methanol, RT, 30 min

With pyridine; sodium azide; bisacodyl; water; sodium methylate; Iodine monochloride; 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00086a013

Reference yield:

: 140226-18-2
2',5'-dideoxy-5'-iodoadenosine

: 130108-73-5
4'-azido-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / sodium methoxide / methanol / 16 h / Heating

2: iodine monochloride, sodium azide / dimethylformamide / 1 h / Ambient temperature

3: DAMP, pyridine

4: 1.) m-chloroperbenzoic acid, water, 2.) sodium methoxide / 1.) dichloromethane, RT, 3.5 h, 2.) methanol, RT, 30 min

With pyridine; sodium azide; bisacodyl; water; sodium methylate; Iodine monochloride; 3-chloro-benzenecarboperoxoic acid; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00086a013

Reference yield:

: 958-09-8,7005-15-4
2'-deoxy-D-adenosine

: 130108-73-5
4'-azido-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 5 steps

1: 29 percent / triphenylphosphine, iodine, pyridine / dioxane / 7 h / Ambient temperature

2: 78 percent / sodium methoxide / methanol / 16 h / Heating

3: iodine monochloride, sodium azide / dimethylformamide / 1 h / Ambient temperature

4: DAMP, pyridine

5: 1.) m-chloroperbenzoic acid, water, 2.) sodium methoxide / 1.) dichloromethane, RT, 3.5 h, 2.) methanol, RT, 30 min

With pyridine; sodium azide; bisacodyl; water; iodine; sodium methylate; Iodine monochloride; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00086a013