Technology Process of (E)-N-benzhydryl-5-iodopent-4-en-1-amine
There total 3 articles about (E)-N-benzhydryl-5-iodopent-4-en-1-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-benzhydrylpent-4-yn-1-amine;
With
zirconocene dichloride; diisobutylaluminium hydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1h;
Inert atmosphere;
With
iodine;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol301385g
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / dichloromethane / 2 h / -10 °C / Inert atmosphere
2.1: sodium iodide / dimethyl sulfoxide / 55 °C / Inert atmosphere
3.1: zirconocene dichloride; diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
3.2: 1 h / -78 - 20 °C / Inert atmosphere
With
zirconocene dichloride; diisobutylaluminium hydride; triethylamine; sodium iodide;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol301385g
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium iodide / dimethyl sulfoxide / 55 °C / Inert atmosphere
2.1: zirconocene dichloride; diisobutylaluminium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 1 h / -78 - 20 °C / Inert atmosphere
With
zirconocene dichloride; diisobutylaluminium hydride; sodium iodide;
In
tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/ol301385g
