6-chloro-7,8-dihydroxy-3-(2-furanylmethyl)-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:6-chloro-7,8-dihydroxy-3-(2-furanylmethyl)-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:80751-86-6
Molecular Formula:C₂₂H₂₂ClNO₃
Molecular Weight:383.875
Hs Code.:

Synonyms:6-chloro-7,8-dihydroxy-3-(2-furanylmethyl)-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Chemical Property of 6-chloro-7,8-dihydroxy-3-(2-furanylmethyl)-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

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Technology Process of 6-chloro-7,8-dihydroxy-3-(2-furanylmethyl)-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 9 articles about 6-chloro-7,8-dihydroxy-3-(2-furanylmethyl)-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (6-Chloro-7,8-dihydroxy-1-m-tolyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-furan-2-yl-methanone

: 80751-86-6
6-chloro-7,8-dihydroxy-3-(2-furanylmethyl)-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With borane; In tetrahydrofuran; at 25 ℃; for 3h;
DOI:10.1021/jm00346a005

Reference yield:

: 88-14-2
2-furanoic acid

: 80751-86-6
6-chloro-7,8-dihydroxy-3-(2-furanylmethyl)-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: DCC / tetrahydrofuran

2: 86 percent / NaHCO₃ / H₂O; 2-methoxy-ethanol / 4 h / 25 °C

3: BBr₃ / CH₂Cl₂ / 1 h / 25 °C

4: 1 M BH₃ / tetrahydrofuran / 3 h / 25 °C

With borane; boron tribromide; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; 2-methoxy-ethanol; water;
DOI:10.1021/jm00346a005

Reference yield:

: 704898-29-3,1195902-12-5,20697-03-4
3-methylstyrene oxide

: 80751-86-6
6-chloro-7,8-dihydroxy-3-(2-furanylmethyl)-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 18 h / 110 °C

2: H₂SO₄, CF₃COOH / 2 h / Heating

3: 86 percent / NaHCO₃ / H₂O; 2-methoxy-ethanol / 4 h / 25 °C

4: BBr₃ / CH₂Cl₂ / 1 h / 25 °C

5: 1 M BH₃ / tetrahydrofuran / 3 h / 25 °C

With sulfuric acid; borane; boron tribromide; sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 2-methoxy-ethanol; water;
DOI:10.1021/jm00346a005