1-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propan-1-ol

Base Information

Chemical Name:1-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propan-1-ol
CAS No.:1018325-52-4
Molecular Formula:C₂₀H₂₄Cl₂F₃N₃O₂
Molecular Weight:466.331
Hs Code.:

Synonyms:1-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propan-1-ol

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Chemical Property of 1-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propan-1-ol

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Technology Process of 1-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propan-1-ol

There total 2 articles about 1-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 235106-12-4
4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazole

: C₁₈H₂₈ClNO₂Si

: 1018325-52-4
1-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propan-1-ol

: 1018325-62-6
1-(1-(2-bromo-4-chloro-5-methoxyphenyl)piperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propan-1-one

Guidance literature:: C₁₈H₂₈ClNO₂Si; With N-Bromosuccinimide; sodium carbonate; In tetrahydrofuran; at 0 ℃; for 0.5h;

4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazole; With potassium carbonate; In acetonitrile; at 20 ℃;

Reference yield:

: 1018325-56-8
1-(4-chloro-3-methoxyphenyl)piperidine-4-carboxylic acid

: 1018325-52-4
1-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-2-(4-chloro-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 0 - 20 °C

2.1: tetrahydrofuran; diethyl ether / 0.87 h / -78 - 0 °C

2.2: 0.08 h

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes / 0.67 h / -78 °C

3.2: 0.5 h

4.1: N-Bromosuccinimide; sodium carbonate / tetrahydrofuran / 0.5 h / 0 °C

4.2: 20 °C

With dmap; N-Bromosuccinimide; n-butyllithium; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diisopropylamine; In tetrahydrofuran; hexanes; diethyl ether; dichloromethane;