(2-benzylamino-6-methyl-pyrimidin-4-yloxy)-acetic acid hydrazide

Base Information

• Chemical Name: (2-benzylamino-6-methyl-pyrimidin-4-yloxy)-acetic acid hydrazide
• CAS No.: 347846-60-0
• Molecular Formula: C₁₄H₁₇N₅O₂
• Molecular Weight: 287.321
• Mol file: 347846-60-0.mol

Synonyms:(2-benzylamino-6-methyl-pyrimidin-4-yloxy)-acetic acid hydrazide

Chemical Property of (2-benzylamino-6-methyl-pyrimidin-4-yloxy)-acetic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-benzylamino-6-methyl-pyrimidin-4-yloxy)-acetic acid hydrazide

There total 4 articles about (2-benzylamino-6-methyl-pyrimidin-4-yloxy)-acetic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(2-benzylamino-6-methyl-pyrimidin-4-yloxy)-acetic acid methyl ester (616872-60-7) → (2-benzylamino-6-methyl-pyrimidin-4-yloxy)-acetic acid hydrazide (347846-60-0)

Guidance literature:

With hydrazine hydrate; In isopropyl alcohol; for 1h; Heating;

DOI:10.1016/S0014-827X(02)00022-8

Reference yield:

benzylamine (100-46-9) → (2-benzylamino-6-methyl-pyrimidin-4-yloxy)-acetic acid hydrazide (347846-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / dimethylsulfoxide / 0.5 h / 50 - 70 °C

2: 76 percent / hydrazine hydrate / propan-2-ol / 1 h / Heating

With hydrazine hydrate; In dimethyl sulfoxide; isopropyl alcohol;

DOI:10.1016/S0014-827X(02)00022-8

Reference yield:

(6-methyl-2-methylsulfanyl-pyrimidin-4-yloxy)-acetic acid methyl ester (54069-06-6) → (2-benzylamino-6-methyl-pyrimidin-4-yloxy)-acetic acid hydrazide (347846-60-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / Cl₂; H₂O / methanol / -5 °C

2: 85 percent / dimethylsulfoxide / 0.5 h / 50 - 70 °C

3: 76 percent / hydrazine hydrate / propan-2-ol / 1 h / Heating

With water; chlorine; hydrazine hydrate; In methanol; dimethyl sulfoxide; isopropyl alcohol;

DOI:10.1016/S0014-827X(02)00022-8

upstream raw materials:

(2-benzylamino-6-methyl-pyrimidin-4-yloxy)-acetic acid methyl ester

benzylamine

(6-methyl-2-methylsulfanyl-pyrimidin-4-yloxy)-acetic acid methyl ester

methyl (6-methyl-2-methylsulfonyl-4-pyrimidinyloxy)acetate

Downstream raw materials:

5-(2-benzylamino-6-methyl-pyrimidin-4-yloxymethyl)-3H-[1,3,4]oxadiazole-2-thione