Technology Process of C25H34FN6O8P
There total 8 articles about C25H34FN6O8P which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C11H14FN5O4;
With
tert-butylmagnesium chloride;
In
tetrahydrofuran;
at -78 - 0 ℃;
for 0.5h;
(2S)-2-{[chloro(1-phenoxy)phosphoryl]amino}propyl pivaloate;
In
tetrahydrofuran;
at -78 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.08 h / -78 °C
1.2: 2 h / -78 °C
2.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 184 h / 20 °C
3.1: ammonia / 16 h / 50 °C / Sealed tube
3.2: 0.67 h / 60 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
5.1: ammonia / 72 h / 115 °C / Sealed tube
6.1: water / bovine spleen type IX sdenosine deaminase A5168 / 4 h / 37 °C / Enzymatic reaction
7.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / -78 - 0 °C
7.2: -78 °C
With
triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; tert-butylmagnesium chloride; ammonia; water; 3-chloro-benzenecarboperoxoic acid;
bovine spleen type IX sdenosine deaminase A5168;
In
tetrahydrofuran; hexanes; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.08 h / -78 °C
1.2: 2 h / -78 °C
2.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 184 h / 20 °C
3.1: ammonia / 16 h / 50 °C / Sealed tube
3.2: 0.67 h / 60 °C
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
5.1: ammonia / 72 h / 115 °C / Sealed tube
6.1: water / bovine spleen type IX sdenosine deaminase A5168 / 4 h / 37 °C / Enzymatic reaction
7.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / -78 - 0 °C
7.2: -78 °C
With
triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; tert-butylmagnesium chloride; ammonia; water; 3-chloro-benzenecarboperoxoic acid;
bovine spleen type IX sdenosine deaminase A5168;
In
tetrahydrofuran; hexanes; dichloromethane;