(-)-(R)-N-<3-(2-azido-1-hydroxyethyl)-4-fluorophenyl>methanesulfonamide

Base Information

Chemical Name:(-)-(R)-N-<3-(2-azido-1-hydroxyethyl)-4-fluorophenyl>methanesulfonamide
CAS No.:175692-94-1
Molecular Formula:C₉H₁₁FN₄O₃S
Molecular Weight:274.276
Hs Code.:

Synonyms:(-)-(R)-N-<3-(2-azido-1-hydroxyethyl)-4-fluorophenyl>methanesulfonamide

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Chemical Property of (-)-(R)-N-<3-(2-azido-1-hydroxyethyl)-4-fluorophenyl>methanesulfonamide

Chemical Property:

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Technology Process of (-)-(R)-N-<3-(2-azido-1-hydroxyethyl)-4-fluorophenyl>methanesulfonamide

There total 3 articles about (-)-(R)-N-<3-(2-azido-1-hydroxyethyl)-4-fluorophenyl>methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 175692-93-0
(-)-(R)-N-<3-(2-chloro-1-hydroxyethyl)-4-fluorophenyl>methanesulfonamide

: 175692-94-1
(-)-(R)-N-<3-(2-azido-1-hydroxyethyl)-4-fluorophenyl>methanesulfonamide

Guidance literature:: With sodium azide; tetra-(n-butyl)ammonium iodide; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 100 ℃; for 48h;
DOI:10.1080/00397919608003734

Reference yield:

: 137314-93-3
N-(3-acetyl-4-fluorophenyl)methanesulfonamide

: 175692-94-1
(-)-(R)-N-<3-(2-azido-1-hydroxyethyl)-4-fluorophenyl>methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / SO₂Cl₂, MeOH / CH₂Cl₂ / 28 h / Heating

2: 92 percent / (-)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 1.) -20 deg C, 12 h, 2.) room temperature, 24 h

3: 71 percent / NaN₃, Bu₄NI / hexamethylphosphoric acid triamide / 48 h / 100 °C

With methanol; sodium azide; sulfuryl dichloride; tetra-(n-butyl)ammonium iodide; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1080/00397919608003734

Reference yield:

: 175692-92-9
N-(3-chloroacetyl-4-fluorophenyl)methanesulfonamide

: 175692-94-1
(-)-(R)-N-<3-(2-azido-1-hydroxyethyl)-4-fluorophenyl>methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / (-)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 1.) -20 deg C, 12 h, 2.) room temperature, 24 h

2: 71 percent / NaN₃, Bu₄NI / hexamethylphosphoric acid triamide / 48 h / 100 °C

With sodium azide; tetra-(n-butyl)ammonium iodide; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1080/00397919608003734