(S)-2-((S)-2-{(S)-1-[(1S,2S)-1-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(S)-2-((S)-2-{(S)-1-[(1S,2S)-1-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:90600-29-6
Molecular Formula:C₄₆H₆₅N₇O₁₀
Molecular Weight:876.063
Hs Code.:

(S)-2-((S)-2-{(S)-1-[(1S,2S)-1-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:(S)-2-((S)-2-{(S)-1-[(1S,2S)-1-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-2-((S)-2-{(S)-1-[(1S,2S)-1-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (S)-2-((S)-2-{(S)-1-[(1S,2S)-1-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 1 articles about (S)-2-((S)-2-{(S)-1-[(1S,2S)-1-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1842-55-3
glycylglycine benzyl ester

: 90600-38-7
Boc-L-Pro-L-Pro-L-Phe-L-Ile-L-Val-OH

: 90600-29-6
(S)-2-((S)-2-{(S)-1-[(1S,2S)-1-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 3h;
DOI:10.1246/bcsj.57.815

Reference yield: 98.0%

: 90600-29-6
(S)-2-((S)-2-{(S)-1-[(1S,2S)-1-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: (2-{(S)-3-Methyl-2-[(2S,3S)-3-methyl-2-((S)-3-phenyl-2-{[(S)-1-((S)-pyrrolidine-2-carbonyl)-pyrrolidine-2-carbonyl]-amino}-propionylamino)-pentanoylamino]-butyrylamino}-acetylamino)-acetic acid benzyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; formic acid; In 1,4-dioxane; for 0.5h;
DOI:10.1246/bcsj.57.815

Reference yield:

: 90600-29-6
(S)-2-((S)-2-{(S)-1-[(1S,2S)-1-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-2-phenyl-ethylcarbamoyl}-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: {2-[(S)-2-((2S,3S)-2-{(S)-2-[((S)-1-{(S)-1-[2-((S)-2-Amino-5-guanidino-pentanoylamino)-acetyl]-pyrrolidine-2-carbonyl}-pyrrolidine-2-carbonyl)-amino]-3-phenyl-propionylamino}-3-methyl-pentanoylamino)-3-methyl-butyrylamino]-acetylamino}-acetic acid; compound with acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / 98percent formic acid, 3.5M hydrogen chloride / dioxane / 0.5 h

2: 83 percent / N-methylmorpholine, 1-hydroxybenzotriazole, DCC / dimethylformamide / 3 h / 0 °C

3: 83 percent / H₂ / palladium black / methanol / 24 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; formic acid; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.57.815