Technology Process of (2R,3R,4R)-1-O-benzyl-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3,4-tetrol
There total 7 articles about (2R,3R,4R)-1-O-benzyl-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3,4-tetrol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-bromo-4-methoxy-benzene;
With
iodine; magnesium;
In
tetrahydrofuran;
1-O-benzyl-2,3-O-isopropylidene-4-oxiranyl-D-arabinitol;
With
copper(l) iodide;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1016/j.tetasy.2005.08.039
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 860 mg / potassium carbonate / methanol / 0.5 h / 20 °C
2.1: magnesium; iodine / tetrahydrofuran
2.2: 86 percent / copper(I) iodide / tetrahydrofuran / 0 - 20 °C
With
iodine; potassium carbonate; magnesium;
In
tetrahydrofuran; methanol;
2.2: Crignard reaction;
DOI:10.1016/j.tetasy.2005.08.039
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 84 percent / sodium hydride / dimethylformamide / 20 °C
2.1: 84 percent / acetic acid / H2O / 20 °C
3.1: triethylamine / CH2Cl2 / 16 h / 20 °C
4.1: 860 mg / potassium carbonate / methanol / 0.5 h / 20 °C
5.1: magnesium; iodine / tetrahydrofuran
5.2: 86 percent / copper(I) iodide / tetrahydrofuran / 0 - 20 °C
With
iodine; sodium hydride; potassium carbonate; magnesium; acetic acid; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
5.2: Crignard reaction;
DOI:10.1016/j.tetasy.2005.08.039
