(2R,3R,4R)-1-O-benzyl-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3,4-tetrol

Base Information

Chemical Name:(2R,3R,4R)-1-O-benzyl-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3,4-tetrol
CAS No.:869660-96-8
Molecular Formula:C₂₂H₂₈O₅
Molecular Weight:372.461
Hs Code.:

Synonyms:(2R,3R,4R)-1-O-benzyl-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3,4-tetrol

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Chemical Property of (2R,3R,4R)-1-O-benzyl-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3,4-tetrol

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Technology Process of (2R,3R,4R)-1-O-benzyl-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3,4-tetrol

There total 7 articles about (2R,3R,4R)-1-O-benzyl-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3,4-tetrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 869660-95-7
1-O-benzyl-2,3-O-isopropylidene-4-oxiranyl-D-arabinitol

: 104-92-7
1-bromo-4-methoxy-benzene

: 869660-96-8
(2R,3R,4R)-1-O-benzyl-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3,4-tetrol

Guidance literature:: 1-bromo-4-methoxy-benzene; With iodine; magnesium; In tetrahydrofuran;

1-O-benzyl-2,3-O-isopropylidene-4-oxiranyl-D-arabinitol; With copper(l) iodide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.tetasy.2005.08.039

Reference yield:

: Toluene-4-sulfonic acid (R)-2-((4R,5R)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-ethyl ester

: 869660-96-8
(2R,3R,4R)-1-O-benzyl-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3,4-tetrol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 860 mg / potassium carbonate / methanol / 0.5 h / 20 °C

2.1: magnesium; iodine / tetrahydrofuran

2.2: 86 percent / copper(I) iodide / tetrahydrofuran / 0 - 20 °C

With iodine; potassium carbonate; magnesium; In tetrahydrofuran; methanol; 2.2: Crignard reaction;
DOI:10.1016/j.tetasy.2005.08.039

Reference yield:

: 19139-74-3
2,3:4,5-di-O-isopropylidene-D-arabinitol

: 869660-96-8
(2R,3R,4R)-1-O-benzyl-2,3-O-isopropylidene-5-(4-methoxyphenyl)pentane-1,2,3,4-tetrol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 84 percent / sodium hydride / dimethylformamide / 20 °C

2.1: 84 percent / acetic acid / H₂O / 20 °C

3.1: triethylamine / CH₂Cl₂ / 16 h / 20 °C

4.1: 860 mg / potassium carbonate / methanol / 0.5 h / 20 °C

5.1: magnesium; iodine / tetrahydrofuran

5.2: 86 percent / copper(I) iodide / tetrahydrofuran / 0 - 20 °C

With iodine; sodium hydride; potassium carbonate; magnesium; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 5.2: Crignard reaction;
DOI:10.1016/j.tetasy.2005.08.039