(2R,3R,4R)-3-(4-methoxybenzyloxy)-2,4-dimethylhex-5-en-1-ol

Base Information

• Chemical Name: (2R,3R,4R)-3-(4-methoxybenzyloxy)-2,4-dimethylhex-5-en-1-ol
• CAS No.: 1321532-02-8
• Molecular Formula: C₁₆H₂₄O₃
• Molecular Weight: 264.365
• Mol file: 1321532-02-8.mol

Synonyms:(2R,3R,4R)-3-(4-methoxybenzyloxy)-2,4-dimethylhex-5-en-1-ol

Chemical Property of (2R,3R,4R)-3-(4-methoxybenzyloxy)-2,4-dimethylhex-5-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R,4R)-3-(4-methoxybenzyloxy)-2,4-dimethylhex-5-en-1-ol

There total 2 articles about (2R,3R,4R)-3-(4-methoxybenzyloxy)-2,4-dimethylhex-5-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl((2R,3R,4R)-3-(4-methoxybenzyloxy)-2,4-dimethylhex-5-enyloxy)dimethylsilane → (2R,3R,4R)-3-(4-methoxybenzyloxy)-2,4-dimethylhex-5-en-1-ol (1321532-02-8)

Guidance literature:

With methanol; 10-camphorsufonic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ja204570w

Reference yield:

(2R,3R,4R)-1-(tert-butyldimethylsilyloxy)-2,4-dimethylhex-5-en-3-ol (152377-62-3) → (2R,3R,4R)-3-(4-methoxybenzyloxy)-2,4-dimethylhex-5-en-1-ol (1321532-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: methanol; 10-camphorsufonic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With methanol; 10-camphorsufonic acid; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja204570w

Reference yield:

(2R,3R,4R)-3-(4-methoxybenzyloxy)-2,4-dimethylhex-5-en-1-ol (1321532-02-8) → (2R,3R,4S)-3-(4-methoxybenzyloxy)-2,4-dimethylhex-5-enal

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/ja204570w

upstream raw materials:

(2R,3R,4R)-1-(tert-butyldimethylsilyloxy)-2,4-dimethylhex-5-en-3-ol