(4-methyl-2-(methylamino)phenyl)(phenyl)methanone

Base Information

• Chemical Name: (4-methyl-2-(methylamino)phenyl)(phenyl)methanone
• CAS No.: 50817-62-4
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.29
• Mol file: 50817-62-4.mol

Synonyms:(4-methyl-2-(methylamino)phenyl)(phenyl)methanone

Chemical Property of (4-methyl-2-(methylamino)phenyl)(phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (4-methyl-2-(methylamino)phenyl)(phenyl)methanone

There total 4 articles about (4-methyl-2-(methylamino)phenyl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-methyl-N-nitroso-N-methylaniline (17485-25-5) + toluene (108-88-3,15644-74-3,16713-13-6) → (4-methyl-2-(methylamino)phenyl)(phenyl)methanone (50817-62-4)

Guidance literature:

With tert.-butylhydroperoxide; palladium diacetate; at 80 ℃; for 24h; Schlenk technique;

DOI:10.1039/c4cc07440h

Reference yield: 60.0%

N-methyl-m-toluidine (696-44-6) + Benzoylformic acid (611-73-4) → (4-methyl-2-(methylamino)phenyl)(phenyl)methanone (50817-62-4)

Guidance literature:

N-methyl-m-toluidine; Benzoylformic acid; With 2-Methyl-2-nitropropane; palladium diacetate; In 1,2-dichloro-ethane; at 40 ℃; for 20h; Sealed tube;

With iron; ammonium chloride; In 1,2-dichloro-ethane; at 80 ℃; for 10h;

Reference yield: 60.0%

N-(2-benzoyl-5-methylphenyl)-N-methylnitrous amide → (4-methyl-2-(methylamino)phenyl)(phenyl)methanone (50817-62-4)

Guidance literature:

With iron; ammonium chloride; In 1,2-dichloro-ethane; at 80 ℃; for 10h; Sealed tube;

DOI:10.1039/c8ob01846d

upstream raw materials:

3-methyl-N-nitroso-N-methylaniline

toluene

N-methyl-m-toluidine

Benzoylformic acid

Refernces

• 1、 Wang, Qianqian,Zhang, Xinying,Fan, Xuesen. "Synthesis of 2-aminobenzophenones through acylation of anilines with α-oxocarboxylic acids assisted by: Tert -butyl nitrite". . p. 7737 - 7747. Retrieved 2018/11/02.