α-{4-[2-(4-ethyl-1-piperazinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.1^3,7]decanemethanol

Base Information

• Chemical Name: α-{4-[2-(4-ethyl-1-piperazinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.1^3,7]decanemethanol
• CAS No.: 1410789-60-4
• Molecular Formula: C₃₁H₄₂N₂O
• Molecular Weight: 458.687

Synonyms:α-{4-[2-(4-ethyl-1-piperazinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.1^3,7]decanemethanol

Chemical Property of α-{4-[2-(4-ethyl-1-piperazinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.1^3,7]decanemethanol

Chemical Property:

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Technology Process of α-{4-[2-(4-ethyl-1-piperazinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.1^3,7]decanemethanol

There total 5 articles about α-{4-[2-(4-ethyl-1-piperazinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.1^3,7]decanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzoyladamantane (31919-47-8) + C14H21LiN2 → α-{4-[2-(4-ethyl-1-piperazinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.13,7]decanemethanol (1410789-60-4)

Guidance literature:

1-benzoyladamantane; C₁₄H₂₁LiN₂; In tetrahydrofuran; at -80 - 20 ℃; for 2.5h;

With ammonium chloride; In tetrahydrofuran; at 0 ℃;

DOI:10.1021/jm3013008

Reference yield:

4-bromophenethanol (4654-39-1) → α-{4-[2-(4-ethyl-1-piperazinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.13,7]decanemethanol (1410789-60-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 12.5 h / 0 - 4 °C

2.1: tetrahydrofuran / Reflux

3.1: tert.-butyl lithium / tetrahydrofuran; hexane / 2 h / -80 °C / Inert atmosphere

4.1: tetrahydrofuran / 2.5 h / -80 - 20 °C

4.2: 0 °C

With pyridine; tert.-butyl lithium; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jm3013008

Reference yield:

1-ethylpiperazine trifluoroacetate (1410789-57-9) → α-{4-[2-(4-ethyl-1-piperazinyl)ethyl]phenyl}-α-phenyl-1-tricyclo[3.3.1.13,7]decanemethanol (1410789-60-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic acid; 1-methyl-pyrrolidin-2-one / 12.33 h / 0 - 60 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; hexane / 2 h / -80 °C / Inert atmosphere

3.1: tetrahydrofuran / 2.5 h / -80 - 20 °C

3.2: 0 °C

With 1-methyl-pyrrolidin-2-one; tert.-butyl lithium; trifluoroacetic acid; In tetrahydrofuran; hexane;

DOI:10.1021/jm3013008

upstream raw materials:

4-bromophenethanol

1-ethylpiperazine trifluoroacetate

1-benzoyladamantane

1-ethyl-4-(4-bromophenylethyl)piperazine

Downstream raw materials:

C₃₁H₄₂N₂

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