3-methoxy-11-oxo-5-benzyl-11-hydro-benzo[4,5]imidazo[1,2-b]isoquinoline-6(5H)-carboxylic acid ethyl ester

Base Information

Chemical Name:3-methoxy-11-oxo-5-benzyl-11-hydro-benzo[4,5]imidazo[1,2-b]isoquinoline-6(5H)-carboxylic acid ethyl ester
CAS No.:1429436-61-2
Molecular Formula:C₂₆H₂₂N₂O₄
Molecular Weight:426.472
Hs Code.:

Synonyms:3-methoxy-11-oxo-5-benzyl-11-hydro-benzo[4,5]imidazo[1,2-b]isoquinoline-6(5H)-carboxylic acid ethyl ester

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Chemical Property of 3-methoxy-11-oxo-5-benzyl-11-hydro-benzo[4,5]imidazo[1,2-b]isoquinoline-6(5H)-carboxylic acid ethyl ester

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Technology Process of 3-methoxy-11-oxo-5-benzyl-11-hydro-benzo[4,5]imidazo[1,2-b]isoquinoline-6(5H)-carboxylic acid ethyl ester

There total 5 articles about 3-methoxy-11-oxo-5-benzyl-11-hydro-benzo[4,5]imidazo[1,2-b]isoquinoline-6(5H)-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1429436-41-8
C₂₆H₂₅N₃O₄

: 1429436-61-2
3-methoxy-11-oxo-5-benzyl-11-hydro-benzo[4,5]imidazo[1,2-b]isoquinoline-6(5H)-carboxylic acid ethyl ester

Guidance literature:: With Amberlyst-15; In acetonitrile; at 60 ℃; for 4h; Inert atmosphere;
DOI:10.1039/c3cc41337c

Reference yield:

: 1429436-32-7
ethyl 3-amino-2-(2-amino-4-methoxyphenyl)-1-oxo-1,2-dihydroisoquinoline-4-carboxylate

: 1429436-61-2
3-methoxy-11-oxo-5-benzyl-11-hydro-benzo[4,5]imidazo[1,2-b]isoquinoline-6(5H)-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: Amberlyst-15 / acetonitrile / 4 h / 60 °C / Inert atmosphere

With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3cc41337c

Reference yield:

: 102-51-2
4-methoxy-1,2-phenylenediamine

: 1429436-61-2
3-methoxy-11-oxo-5-benzyl-11-hydro-benzo[4,5]imidazo[1,2-b]isoquinoline-6(5H)-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 3 h / 85 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4: Amberlyst-15 / acetonitrile / 4 h / 60 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3cc41337c