5-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-2-amino-1,3,4-oxadiazole

Base Information

Chemical Name:5-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-2-amino-1,3,4-oxadiazole
CAS No.:1345041-90-8
Molecular Formula:C₁₇H₁₄ClN₅O
Molecular Weight:339.784
Hs Code.:

Synonyms:5-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-2-amino-1,3,4-oxadiazole

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Chemical Property of 5-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-2-amino-1,3,4-oxadiazole

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Technology Process of 5-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-2-amino-1,3,4-oxadiazole

There total 5 articles about 5-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-2-amino-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: cyanogen bromide

: 1345041-77-1
5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazole-3-carbohydrazide

: 1345041-90-8
5-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-2-amino-1,3,4-oxadiazole

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; at 25 - 30 ℃; for 3.08333h;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester

: 1345041-90-8
5-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-2-amino-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 4 h / Reflux

2: sodium carbonate / 1,4-dioxane; water / 3.08 h / 25 - 30 °C

With sodium carbonate; hydrazine hydrate; In 1,4-dioxane; ethanol; water;
DOI:10.1016/j.bmcl.2011.08.061

Reference yield:

: 133678-11-2
ethyl 2-oxo-4-(p-chlorophenyl)but-3-enoate

: 1345041-90-8
5-(5-(4-chlorophenyl)-4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-2-amino-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 2 h / 25 - 30 °C / Inert atmosphere

1.2: 10 h / Inert atmosphere; Reflux

2.1: hydrazine hydrate / ethanol / 4 h / Reflux

3.1: sodium carbonate / 1,4-dioxane; water / 3.08 h / 25 - 30 °C

With sodium carbonate; hydrazine hydrate; In 1,4-dioxane; ethanol; water;
DOI:10.1016/j.bmcl.2011.08.061