Technology Process of ABT-737
There total 4 articles about ABT-737 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
at 20 ℃;
for 48h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium hydroxide monohydrate; water; methanol / tetrahydrofuran / 24 h / 20 °C
1.2: 24 h / 20 °C
2.1: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
2.2: 24 h / 20 °C
3.1: sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 24 h / 25 °C / Inert atmosphere
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 48 h / 20 °C
With
hydrogenchloride; methanol; dmap; sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex; lithium hydroxide monohydrate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C
1.2: 24 h / 20 °C
2.1: sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 24 h / 25 °C / Inert atmosphere
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 48 h / 20 °C
With
hydrogenchloride; dmap; sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
