(4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)(pyrrolidin-1-yl)methanone

Base Information

Chemical Name:(4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)(pyrrolidin-1-yl)methanone
CAS No.:1312782-43-6
Molecular Formula:C₂₀H₂₀N₄O₂
Molecular Weight:348.404
Hs Code.:

Synonyms:(4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)(pyrrolidin-1-yl)methanone

Suppliers and Price of (4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)(pyrrolidin-1-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of (4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)(pyrrolidin-1-yl)methanone

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

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Technology Process of (4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)(pyrrolidin-1-yl)methanone

There total 2 articles about (4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)(pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: (1-benzyl-1H-[1,2,3]triazol-4-yl)-diphenyl-methanol

: 1192-63-8
1-pyrrolidinecarbonyl chloride

: 1312782-43-6
(4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)(pyrrolidin-1-yl)methanone

Guidance literature:: (1-benzyl-1H-[1,2,3]triazol-4-yl)-diphenyl-methanol; With palladium 10% on activated carbon; hydrogen; In ethanol; for 20h; Inert atmosphere;

1-pyrrolidinecarbonyl chloride; With dmap; triethylamine; In tetrahydrofuran; at 60 ℃; for 10h;
DOI:10.1016/j.tet.2014.10.076

Reference yield:

: 3923-52-2
1,1-diphenyl-2-propyn-1-ol

: 1312782-43-6
(4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.08 h / -90 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 20 h / Inert atmosphere

2.2: 10 h / 60 °C

With trimethylsilyl trifluoromethanesulfonate; palladium 10% on activated carbon; hydrogen; In ethanol; dichloromethane;
DOI:10.1016/j.tet.2014.10.076