4-[1-[[2-(3-chlorophenyl)-5-(trifluormethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluorobenzamide

Base Information

Chemical Name:4-[1-[[2-(3-chlorophenyl)-5-(trifluormethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluorobenzamide
CAS No.:1255040-62-0
Molecular Formula:C₂₁H₁₇ClF₄N₄O₂
Molecular Weight:468.838
Hs Code.:

Synonyms:4-[1-[[2-(3-chlorophenyl)-5-(trifluormethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluorobenzamide

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Chemical Property of 4-[1-[[2-(3-chlorophenyl)-5-(trifluormethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluorobenzamide

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Technology Process of 4-[1-[[2-(3-chlorophenyl)-5-(trifluormethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluorobenzamide

There total 12 articles about 4-[1-[[2-(3-chlorophenyl)-5-(trifluormethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₁₅Cl₂F₄N₃O₂

: 1255040-62-0
4-[1-[[2-(3-chlorophenyl)-5-(trifluormethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluorobenzamide

Guidance literature:: With ammonia; In 1,4-dioxane; at 23 ℃; for 2h;

Reference yield:

: 95037-98-2
ethyl 2-(4-amino-3-fluorophenyl)propionate

: 1255040-62-0
4-[1-[[2-(3-chlorophenyl)-5-(trifluormethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 7 steps

1: sulfuric acid; potassium iodide; sodium nitrite / water / 0 - 23 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 8 h / Reflux

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 40 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 23 °C

5: ethanol; sodium hydroxide / 100 °C

6: thionyl chloride / dichloromethane / 2 h / Reflux

7: ammonia / 1,4-dioxane / 2 h / 23 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; lithium hydroxide monohydrate; ethanol; sulfuric acid; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1402585-20-9
2-(4-cyano-3-fluorophenyl)propanoic acid

: 1255040-62-0
4-[1-[[2-(3-chlorophenyl)-5-(trifluormethyl)-2H-pyrazol-3-yl]methylcarbamoyl]ethyl]-2-fluorobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 23 °C

2: ethanol; sodium hydroxide / 100 °C

3: thionyl chloride / dichloromethane / 2 h / Reflux

4: ammonia / 1,4-dioxane / 2 h / 23 °C

With thionyl chloride; ethanol; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; dichloromethane; acetonitrile;