2'-ethyl-5-{[(5R,7S)-1-(3-fluorophenyl)-7-methyl-2,2-dioxido-2-thia-1,8-diazaspiro[4.5]dec-8-yl]methyl}biphenyl-2-ol

Base Information

Chemical Name:2'-ethyl-5-{[(5R,7S)-1-(3-fluorophenyl)-7-methyl-2,2-dioxido-2-thia-1,8-diazaspiro[4.5]dec-8-yl]methyl}biphenyl-2-ol
CAS No.:1338819-98-9
Molecular Formula:C₂₉H₃₃FN₂O₃S
Molecular Weight:508.657
Hs Code.:

Synonyms:2'-ethyl-5-{[(5R,7S)-1-(3-fluorophenyl)-7-methyl-2,2-dioxido-2-thia-1,8-diazaspiro[4.5]dec-8-yl]methyl}biphenyl-2-ol

Suppliers and Price of 2'-ethyl-5-{[(5R,7S)-1-(3-fluorophenyl)-7-methyl-2,2-dioxido-2-thia-1,8-diazaspiro[4.5]dec-8-yl]methyl}biphenyl-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2'-ethyl-5-{[(5R,7S)-1-(3-fluorophenyl)-7-methyl-2,2-dioxido-2-thia-1,8-diazaspiro[4.5]dec-8-yl]methyl}biphenyl-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2'-ethyl-5-{[(5R,7S)-1-(3-fluorophenyl)-7-methyl-2,2-dioxido-2-thia-1,8-diazaspiro[4.5]dec-8-yl]methyl}biphenyl-2-ol

There total 12 articles about 2'-ethyl-5-{[(5R,7S)-1-(3-fluorophenyl)-7-methyl-2,2-dioxido-2-thia-1,8-diazaspiro[4.5]dec-8-yl]methyl}biphenyl-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1338819-96-7
2'-ethyl-5-{[(5R,7S)-1-(3-fluorophenyl)-7-methyl-2,2-dioxido-2-thia-1,8-diazaspiro[4.5]dec-3-en-8-yl]methyl}biphenyl-2-ol

: 1338819-98-9
2'-ethyl-5-{[(5R,7S)-1-(3-fluorophenyl)-7-methyl-2,2-dioxido-2-thia-1,8-diazaspiro[4.5]dec-8-yl]methyl}biphenyl-2-ol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 - 30 ℃; under 760.051 Torr;

Reference yield:

: 921599-74-8,852051-10-6
benzyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate

: 1338819-98-9
2'-ethyl-5-{[(5R,7S)-1-(3-fluorophenyl)-7-methyl-2,2-dioxido-2-thia-1,8-diazaspiro[4.5]dec-8-yl]methyl}biphenyl-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1: acetic acid / 18 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 19 h / 0 - 40 °C

3: lithium hydroxide; water / tetrahydrofuran / 18 h / Reflux

4: hydrogenchloride; water / methanol / 0.5 h

5: sodium tetrahydroborate; methanol / 1 h / 20 °C

6: triethylamine / dichloromethane / 1 h / 0 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 0 °C

8: hydrogenchloride / 1,4-dioxane; water / 3 h / Reflux

9: acetic acid / 1,2-dichloro-ethane / 25 - 50 °C

10: hydrogen; palladium 10% on activated carbon / methanol / 20 - 30 °C / 760.05 Torr

With 2,6-dimethylpyridine; hydrogenchloride; methanol; sodium tetrahydroborate; palladium 10% on activated carbon; water; hydrogen; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 1193782-19-2
benzyl (2S,4R)-4-cyano-4-[(3-fluorophenyl)amino]-2-methyl-piperidine-1-carboxylate

: 1338819-98-9
2'-ethyl-5-{[(5R,7S)-1-(3-fluorophenyl)-7-methyl-2,2-dioxido-2-thia-1,8-diazaspiro[4.5]dec-8-yl]methyl}biphenyl-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 2,6-dimethylpyridine / dichloromethane / 19 h / 0 - 40 °C

2: sodium methylate; sodium hydrogencarbonate / methanol; ethyl acetate / 18 h / 20 °C

3: lithium hydroxide; water / tetrahydrofuran / 18 h / Reflux

4: hydrogenchloride; water / methanol / 0.5 h

5: sodium tetrahydroborate; methanol / 1 h / 20 °C

6: triethylamine / dichloromethane / 1 h / 0 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.5 h / 0 °C

8: hydrogenchloride / 1,4-dioxane; water / 3 h / Reflux

9: acetic acid / 1,2-dichloro-ethane / 25 - 50 °C

10: hydrogen; palladium 10% on activated carbon / methanol / 20 - 30 °C / 760.05 Torr

With 2,6-dimethylpyridine; hydrogenchloride; methanol; sodium tetrahydroborate; palladium 10% on activated carbon; water; hydrogen; sodium methylate; sodium hydrogencarbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane;