Methyl (2R,3R,4R)-<5-oxo-4-(phenylthio)-2-propyltetrahydrofuran-3-yl>acetate

Base Information

Chemical Name:Methyl (2R,3R,4R)-<5-oxo-4-(phenylthio)-2-propyltetrahydrofuran-3-yl>acetate
CAS No.:134829-63-3
Molecular Formula:C₁₆H₂₀O₄S
Molecular Weight:308.398
Hs Code.:

Synonyms:Methyl (2R,3R,4R)-<5-oxo-4-(phenylthio)-2-propyltetrahydrofuran-3-yl>acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl (2R,3R,4R)-<5-oxo-4-(phenylthio)-2-propyltetrahydrofuran-3-yl>acetate

Chemical Property:

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Technology Process of Methyl (2R,3R,4R)-<5-oxo-4-(phenylthio)-2-propyltetrahydrofuran-3-yl>acetate

There total 6 articles about Methyl (2R,3R,4R)-<5-oxo-4-(phenylthio)-2-propyltetrahydrofuran-3-yl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89321-71-1
(2S,3S)-3-propyl-2-oxiranemethanol

: 134829-63-3
Methyl (2R,3R,4R)-<5-oxo-4-(phenylthio)-2-propyltetrahydrofuran-3-yl>acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) Ti(O-i-Pr)4 / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) 0 deg C to r.t.; r.t., 2 h

2: NaIO₄, tetrabutylammonium periodate / methanol; H₂O / 1 h / Ambient temperature

3: NaH / 1.) benzene, mineral oil, 0 deg C, 5 min, 2.) benzene, 30 min

4: NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.25 h / 0 °C / other solvents, times, temperatures, bases

With titanium(IV) isopropylate; sodium periodate; sodium hydride; tetrabutylammonium periodite; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; water;
DOI:10.1021/jo00095a022

Reference yield:

: 103-04-8
(phenylthio)acetic acid

: 134829-63-3
Methyl (2R,3R,4R)-<5-oxo-4-(phenylthio)-2-propyltetrahydrofuran-3-yl>acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) Ti(O-i-Pr)4 / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) 0 deg C to r.t.; r.t., 2 h

2: NaIO₄, tetrabutylammonium periodate / methanol; H₂O / 1 h / Ambient temperature

3: NaH / 1.) benzene, mineral oil, 0 deg C, 5 min, 2.) benzene, 30 min

4: NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.25 h / 0 °C / other solvents, times, temperatures, bases

With titanium(IV) isopropylate; sodium periodate; sodium hydride; tetrabutylammonium periodite; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; water;
DOI:10.1021/jo00095a022

Reference yield:

: 134829-38-2
(1R)-1-<1(S)-1,2-Dihydroxyethyl>butyl (phenylthio)acetate

: 134829-63-3
Methyl (2R,3R,4R)-<5-oxo-4-(phenylthio)-2-propyltetrahydrofuran-3-yl>acetate

Guidance literature:: Multi-step reaction with 3 steps

1: NaIO₄, tetrabutylammonium periodate / methanol; H₂O / 1 h / Ambient temperature

2: NaH / 1.) benzene, mineral oil, 0 deg C, 5 min, 2.) benzene, 30 min

3: NaH / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.25 h / 0 °C / other solvents, times, temperatures, bases

With sodium periodate; sodium hydride; tetrabutylammonium periodite; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; water;
DOI:10.1021/jo00095a022