Technology Process of 9--2-N-(phenylacetyl)guanine
There total 11 articles about 9--2-N-(phenylacetyl)guanine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trichloride;
In
dichloromethane;
at -78 ℃;
for 7h;
DOI:10.1039/P19950002281
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 68 percent / Zn, CH3COOH / 4 h / Heating
2: L-Selectride / tetrahydrofuran / -78 °C
3: 60 percent / PPh3, diethyl azodicarboxylate / tetrahydrofuran / 24 h
4: 1) 3-chloroperbenzoic acid, 2) butane-2,3-dione monoxime, N1,N1,N3,N3-tetramethylguanidine / 1) CH2Cl2, room temperature, 1 h, 2) CH3CN, 5 min
5: 72 percent / BCl3 / CH2Cl2 / 7 h / -78 °C
With
1,1,3,3-tetramethylguanidine; boron trichloride; L-Selectride; acetic acid; butane-2,3-dione mono-oxime; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; zinc; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/P19950002281
- Guidance literature:
-
Multi-step reaction with 4 steps
1: L-Selectride / tetrahydrofuran / -78 °C
2: 60 percent / PPh3, diethyl azodicarboxylate / tetrahydrofuran / 24 h
3: 1) 3-chloroperbenzoic acid, 2) butane-2,3-dione monoxime, N1,N1,N3,N3-tetramethylguanidine / 1) CH2Cl2, room temperature, 1 h, 2) CH3CN, 5 min
4: 72 percent / BCl3 / CH2Cl2 / 7 h / -78 °C
With
1,1,3,3-tetramethylguanidine; boron trichloride; L-Selectride; butane-2,3-dione mono-oxime; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1039/P19950002281
