ethyl (αξ,βξ)-α-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-β-hydroxy-α-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-propanoate

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Chemical Name:ethyl (αξ,βξ)-α-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-β-hydroxy-α-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-propanoate
CAS No.:143949-38-6
Molecular Formula:C₂₄H₃₁NO₅S
Molecular Weight:445.58
Hs Code.:

Synonyms:ethyl (αξ,βξ)-α-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-β-hydroxy-α-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-propanoate

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Chemical Property of ethyl (αξ,βξ)-α-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-β-hydroxy-α-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-propanoate

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Technology Process of ethyl (αξ,βξ)-α-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-β-hydroxy-α-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-propanoate

There total 2 articles about ethyl (αξ,βξ)-α-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-β-hydroxy-α-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115-80-0
Triethyl orthopropionate

: 143949-38-6
ethyl (αξ,βξ)-α-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-β-hydroxy-α-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / pivalic acid / toluene / 5 h / 150 °C

2: 1.) LDA / 1.) THF, -68 deg C to -65 deg C, 40 min, 2.) THF, -78 deg C, 40 min

With lithium diisopropyl amide; Trimethylacetic acid; In toluene;
DOI:10.1248/cpb.42.854

Reference yield:

: 143949-37-5
ethyl (αξ,1ξ,3S,5R)-2-methylene-α,3,5-trimethylcyclopentaneacetate

: 88075-95-0
1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde

: 143949-38-6
ethyl (αξ,βξ)-α-<(1ξ,3S,5R)-3,5-dimethyl-2-methylenecyclopentyl>-β-hydroxy-α-methyl-1-(phenylsulfonyl)-1H-pyrrole-3-propanoate

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -65 deg C, 40 min, 2.) -78 deg C, 40 min;
DOI:10.1016/S0040-4039(00)61322-9