(S)-8-Oxo-6-phenyl-1,5,9-triaza-cyclotridecane-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-8-Oxo-6-phenyl-1,5,9-triaza-cyclotridecane-1-carboxylic acid benzyl ester
CAS No.:126610-78-4
Molecular Formula:C₂₄H₃₁N₃O₃
Molecular Weight:409.528
Hs Code.:

Synonyms:(S)-8-Oxo-6-phenyl-1,5,9-triaza-cyclotridecane-1-carboxylic acid benzyl ester

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Chemical Property of (S)-8-Oxo-6-phenyl-1,5,9-triaza-cyclotridecane-1-carboxylic acid benzyl ester

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Technology Process of (S)-8-Oxo-6-phenyl-1,5,9-triaza-cyclotridecane-1-carboxylic acid benzyl ester

There total 25 articles about (S)-8-Oxo-6-phenyl-1,5,9-triaza-cyclotridecane-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 306272-70-8
4-oxo-2-phenyl-3,4,5,6,7,8,10,11-octahydro-2H-1,4a,9-triaza-benzocyclononene-9-carboxylic acid benzyl ester

: 126610-78-4
(S)-8-Oxo-6-phenyl-1,5,9-triaza-cyclotridecane-1-carboxylic acid benzyl ester

Guidance literature:: With sodium cyanoborohydride; In acetic acid;
DOI:10.1246/cl.2000.1104

Reference yield:

: C₂₄H₂₉N₃O₃*H⁽¹⁺⁾

: 126610-78-4
(S)-8-Oxo-6-phenyl-1,5,9-triaza-cyclotridecane-1-carboxylic acid benzyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; for 0.666667h; Yield given; Ambient temperature;
DOI:10.1016/S0040-4039(01)80739-5

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 126610-78-4
(S)-8-Oxo-6-phenyl-1,5,9-triaza-cyclotridecane-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: toluene / 2 h / Heating

2: DMAP / CH₂Cl₂ / 2 h / Ambient temperature

3: dimethylsulfoxide / 1 h / 90 °C

4: 2N NaOH / ethanol / 3 h / 90 °C

5: 79 percent / 2-chloro-N-methylpyridinium iodide / triethylamine; CH₂Cl₂ / 1 h / Ambient temperature

6: H₂/PdCl₂ / methanol / 3 h

7: triethylamine; CH₂Cl₂ / 1 h / 0 - 25 °C

8: K₂CO₃ / methanol / 0.5 h / Ambient temperature

9: PCC / CH₂Cl₂ / 1 h / Ambient temperature

10: CF₃CO₂H / CH₂Cl₂ / 0.5 h / Ambient temperature

11: NaBH₄ / methanol / 0.67 h / Ambient temperature

With dmap; sodium hydroxide; sodium tetrahydroborate; 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; pyridinium chlorochromate; trifluoroacetic acid; palladium dichloride; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; triethylamine; toluene;
DOI:10.1016/S0040-4039(01)80739-5