3-ethyl-6-(methoxymethyl)-1-(4-(pyrrolidin-1-yl)phenyl)-3-aza-bicyclo[3.1.0]hexane

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Chemical Name:3-ethyl-6-(methoxymethyl)-1-(4-(pyrrolidin-1-yl)phenyl)-3-aza-bicyclo[3.1.0]hexane
CAS No.:1259556-17-6
Molecular Formula:C₁₉H₂₈N₂O
Molecular Weight:300.444
Hs Code.:

Synonyms:3-ethyl-6-(methoxymethyl)-1-(4-(pyrrolidin-1-yl)phenyl)-3-aza-bicyclo[3.1.0]hexane

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Chemical Property of 3-ethyl-6-(methoxymethyl)-1-(4-(pyrrolidin-1-yl)phenyl)-3-aza-bicyclo[3.1.0]hexane

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Technology Process of 3-ethyl-6-(methoxymethyl)-1-(4-(pyrrolidin-1-yl)phenyl)-3-aza-bicyclo[3.1.0]hexane

There total 2 articles about 3-ethyl-6-(methoxymethyl)-1-(4-(pyrrolidin-1-yl)phenyl)-3-aza-bicyclo[3.1.0]hexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1259556-64-3
1-(4-(3-acetyl-6-(methoxymethyl)-3-aza-bicyclo[3.1.0]hexan-1-yl)phenyl)pyrrolidin-2-one

: 1259556-17-6
3-ethyl-6-(methoxymethyl)-1-(4-(pyrrolidin-1-yl)phenyl)-3-aza-bicyclo[3.1.0]hexane

Guidance literature:: 1-(4-(3-acetyl-6-(methoxymethyl)-3-aza-bicyclo[3.1.0]hexan-1-yl)phenyl)pyrrolidin-2-one; With dimethylsulfide borane complex; boron trifluoride diethyl etherate; In tetrahydrofuran; at 40 ℃; for 4.33333h; Reflux;

With methanol; In tetrahydrofuran; for 1h; Reflux;

Reference yield:

: 1259556-61-0
tert-butyl 6-(methoxymethyl)-1-(4-(2-oxopyrrolidin-1-yl)phenyl)-3-aza-bicyclo[3.1.0]hexane-3-carboxylate

: 1259556-17-6
3-ethyl-6-(methoxymethyl)-1-(4-(pyrrolidin-1-yl)phenyl)-3-aza-bicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

1.2: Inert atmosphere

2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.33 h / 40 °C

2.2: 6 h / Reflux

2.3: 1 h / Reflux

With boron trifluoride diethyl etherate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;