Technology Process of cis/trans-4-(6-methoxy-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester
There total 5 articles about cis/trans-4-(6-methoxy-pyridin-2-yl)-cyclohexanecarboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen; triethylamine;
palladium 10% on activated carbon;
In
ethyl acetate;
at 20 ℃;
under 750.075 Torr;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
1.2: 12.5 h / -78 - 20 °C
2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere
3.1: water; acetone / 4 h / 20 °C
4.1: potassium carbonate / (1,3-diisopropylimidazol-2-ylidene)(3-chloropyridyl)palladium(II) dichloride / Reflux
5.1: hydrogen / palladium 10% on activated carbon / 20 °C / 750.08 Torr
With
hydrogen; potassium acetate; potassium carbonate; lithium hexamethyldisilazane;
1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; (1,3-diisopropylimidazol-2-ylidene)(3-chloropyridyl)palladium(II) dichloride; palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; water; acetone;
4.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere
2: water; acetone / 4 h / 20 °C
3: potassium carbonate / (1,3-diisopropylimidazol-2-ylidene)(3-chloropyridyl)palladium(II) dichloride / Reflux
4: hydrogen / palladium 10% on activated carbon / 20 °C / 750.08 Torr
With
hydrogen; potassium acetate; potassium carbonate;
1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; (1,3-diisopropylimidazol-2-ylidene)(3-chloropyridyl)palladium(II) dichloride; palladium 10% on activated carbon;
In
1,4-dioxane; water; acetone;
3: Suzuki Coupling;
