(5-nitro-2-furyl)methyl N^ε-(N¹⁰-(trifluoroacetyl)pteroyllysyl)-N,N-bis(2-chloroethyl)phosphorodiamidate

Base Information

• Chemical Name: (5-nitro-2-furyl)methyl N^ε-(N¹⁰-(trifluoroacetyl)pteroyllysyl)-N,N-bis(2-chloroethyl)phosphorodiamidate
• CAS No.: 324770-56-1
• Molecular Formula: C₃₁H₃₄Cl₂F₃N₁₀O₁₀P
• Molecular Weight: 865.547

Synonyms:(5-nitro-2-furyl)methyl N^ε-(N¹⁰-(trifluoroacetyl)pteroyllysyl)-N,N-bis(2-chloroethyl)phosphorodiamidate

Chemical Property of (5-nitro-2-furyl)methyl N^ε-(N¹⁰-(trifluoroacetyl)pteroyllysyl)-N,N-bis(2-chloroethyl)phosphorodiamidate

Chemical Property:

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Technology Process of (5-nitro-2-furyl)methyl N^ε-(N¹⁰-(trifluoroacetyl)pteroyllysyl)-N,N-bis(2-chloroethyl)phosphorodiamidate

There total 6 articles about (5-nitro-2-furyl)methyl N^ε-(N¹⁰-(trifluoroacetyl)pteroyllysyl)-N,N-bis(2-chloroethyl)phosphorodiamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N10-trifluoroacetylpteroic acid (37793-53-6) → (5-nitro-2-furyl)methyl Nε-(N10-(trifluoroacetyl)pteroyllysyl)-N,N-bis(2-chloroethyl)phosphorodiamidate (324770-56-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / 1 h / 0 °C

2: dimethylformamide / 2 h / 0 °C

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm000306g

Reference yield:

lysine methyl ester dihydrochloride (13515-95-2,15445-34-8,26348-70-9,34015-48-0,67396-08-1,130336-19-5) → (5-nitro-2-furyl)methyl Nε-(N10-(trifluoroacetyl)pteroyllysyl)-N,N-bis(2-chloroethyl)phosphorodiamidate (324770-56-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / diisopropylethylamine; 18-crown-6 / acetonitrile / 3 h / -10 °C

2: 64 percent / pig liver esterase; KH₂PO₄; aq. NaOH / acetone / 36 h / 20 °C / pH 7

3: dimethylformamide / 2 h / 0 °C

With sodium hydroxide; potassium dihydrogenphosphate; pig liver esterase; 18-crown-6 ether; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.1021/jm000306g

Reference yield:

C9H12Cl2ClN2O5P → (5-nitro-2-furyl)methyl Nε-(N10-(trifluoroacetyl)pteroyllysyl)-N,N-bis(2-chloroethyl)phosphorodiamidate (324770-56-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / diisopropylethylamine; 18-crown-6 / acetonitrile / 3 h / -10 °C

2: 64 percent / pig liver esterase; KH₂PO₄; aq. NaOH / acetone / 36 h / 20 °C / pH 7

3: dimethylformamide / 2 h / 0 °C

With sodium hydroxide; potassium dihydrogenphosphate; pig liver esterase; 18-crown-6 ether; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.1021/jm000306g

upstream raw materials:

(5-nitro-2-furyl)methyl N^ε-lysyl-N,N-bis(2-chloroethyl)phosphorodiamidate

C₂₁H₁₉F₃N₆O₆

N₁₀-trifluoroacetylpteroic acid

lysine methyl ester dihydrochloride

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