2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-sulfamoylmethyl-phenyl)-propionic acid

Base Information

Chemical Name:2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-sulfamoylmethyl-phenyl)-propionic acid
CAS No.:543720-26-9
Molecular Formula:C₂₅H₂₄N₂O₆S
Molecular Weight:480.541
Hs Code.:

2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-3-(4-sulfamoylmethyl-phenyl)-propionic acid

Synonyms:2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-sulfamoylmethyl-phenyl)-propionic acid

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Chemical Property of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-sulfamoylmethyl-phenyl)-propionic acid

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Technology Process of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-sulfamoylmethyl-phenyl)-propionic acid

There total 5 articles about 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-sulfamoylmethyl-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 543720-25-8
2-amino-3-(4-sulfamoylmethyl-phenyl)-propionic acid

: 543720-26-9
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-sulfamoylmethyl-phenyl)-propionic acid

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 25h;
DOI:10.1021/jo034113n

Reference yield:

: 114791-24-1
diethyl 2-(acetylamino)-2-<<4-(chloromethyl)phenyl>methyl>propanedioic acid

: 543720-26-9
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-sulfamoylmethyl-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 59 percent / sodium sulfite / acetone; H₂O / 3 h / Heating

2.1: phosphorus pentachloride / CH₂Cl₂ / 4.5 h / 0 °C

3.1: 0.647 g / aqueous ammonium hydroxide / CH₂Cl₂ / 3 h / 0 °C

4.1: aqueous HCl / 24 h / Heating

4.2: 88 percent / propylene oxide / ethanol / 4 h / 20 °C

5.1: 85 percent / NaHCO₃ / H₂O; dioxane / 25 h / 20 °C

With hydrogenchloride; ammonium hydroxide; phosphorus pentachloride; sodium hydrogencarbonate; sodium sulfite; In 1,4-dioxane; dichloromethane; water; acetone;
DOI:10.1021/jo034113n

Reference yield:

: 2-acetylamino-2-(4-chlorosulfonylmethyl-benzyl)-malonic acid diethyl ester

: 543720-26-9
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-sulfamoylmethyl-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 0.647 g / aqueous ammonium hydroxide / CH₂Cl₂ / 3 h / 0 °C

2.1: aqueous HCl / 24 h / Heating

2.2: 88 percent / propylene oxide / ethanol / 4 h / 20 °C

3.1: 85 percent / NaHCO₃ / H₂O; dioxane / 25 h / 20 °C

With hydrogenchloride; ammonium hydroxide; sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jo034113n