2-(1-(2-fluorobenzyl)-5-(6-methoxypyridin-3-yl)-1H-pyrazol-3-yl)pyrimidine

Base Information

Chemical Name:2-(1-(2-fluorobenzyl)-5-(6-methoxypyridin-3-yl)-1H-pyrazol-3-yl)pyrimidine
CAS No.:1354041-05-6
Molecular Formula:C₂₀H₁₆FN₅O
Molecular Weight:361.378
Hs Code.:

Synonyms:2-(1-(2-fluorobenzyl)-5-(6-methoxypyridin-3-yl)-1H-pyrazol-3-yl)pyrimidine

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Chemical Property of 2-(1-(2-fluorobenzyl)-5-(6-methoxypyridin-3-yl)-1H-pyrazol-3-yl)pyrimidine

Chemical Property:

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Technology Process of 2-(1-(2-fluorobenzyl)-5-(6-methoxypyridin-3-yl)-1H-pyrazol-3-yl)pyrimidine

There total 4 articles about 2-(1-(2-fluorobenzyl)-5-(6-methoxypyridin-3-yl)-1H-pyrazol-3-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 446-48-0
o-fluorobenzyl bromide

: 1354044-08-8
2-(5-(6-methoxypyridin-3-yl)-1H-pyrazol-3-yl)pyrimidine

: 1354041-05-6
2-(1-(2-fluorobenzyl)-5-(6-methoxypyridin-3-yl)-1H-pyrazol-3-yl)pyrimidine

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃;

Reference yield:

: 34253-03-7
pyrimidine-2-carboxylic acid methyl ester

: 1354041-05-6
2-(1-(2-fluorobenzyl)-5-(6-methoxypyridin-3-yl)-1H-pyrazol-3-yl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / toluene / 0.25 h / 20 °C

1.2: 90 °C

2.1: hydrazine hydrate; acetic acid / methanol / 60 °C

3.1: potassium carbonate / acetonitrile / 80 °C

With potassium carbonate; hydrazine hydrate; acetic acid; lithium hexamethyldisilazane; In methanol; toluene; acetonitrile;

Reference yield:

: 213193-32-9
1‐(6‐methoxypyridin‐3‐yl)ethan‐1‐one

: 1354041-05-6
2-(1-(2-fluorobenzyl)-5-(6-methoxypyridin-3-yl)-1H-pyrazol-3-yl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / toluene / 0.25 h / 20 °C

1.2: 90 °C

2.1: hydrazine hydrate; acetic acid / methanol / 60 °C

3.1: potassium carbonate / acetonitrile / 80 °C

With potassium carbonate; hydrazine hydrate; acetic acid; lithium hexamethyldisilazane; In methanol; toluene; acetonitrile;