17β-acetoxy-15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-triene

Base Information

Chemical Name:17β-acetoxy-15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-triene
CAS No.:1360600-92-5
Molecular Formula:C₂₉H₃₃N₃O₃
Molecular Weight:471.599
Hs Code.:

Synonyms:17β-acetoxy-15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-triene

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Chemical Property of 17β-acetoxy-15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-triene

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Technology Process of 17β-acetoxy-15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-triene

There total 3 articles about 17β-acetoxy-15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1360600-90-3
17β-acetoxy-15β-azido-3-methoxyestra-1,3,5(10)-triene

: 536-74-3
phenylacetylene

: 1360600-92-5
17β-acetoxy-15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-triene

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In toluene; at 111 ℃; for 4h;
DOI:10.1016/j.bmc.2012.01.008

Reference yield:

: 1360600-88-9
15β-azido-3-methoxyestra-1,3,5(10)-trien-17-one

: 1360600-92-5
17β-acetoxy-15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-triene

Guidance literature:: Multi-step reaction with 3 steps

1: potassium borohydride / methanol; dichloromethane / 3 h

2: pyridine / 6 h / 20 °C

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 4 h / 111 °C

With pyridine; copper(l) iodide; potassium borohydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; dichloromethane; toluene;
DOI:10.1016/j.bmc.2012.01.008

Reference yield:

: 17748-68-4
3-methoxy-estra-1,3,5⁽¹⁰⁾,15-tetraen-17-one

: 1360600-92-5
17β-acetoxy-15β-[4-phenyl-1H-1,2,3-triazol-1-yl]-3-methoxyestra-1,3,5(10)-triene

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide; acetic acid / tetrahydrofuran; water / 24 h / 20 °C

2: potassium borohydride / methanol; dichloromethane / 3 h

3: pyridine / 6 h / 20 °C

4: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 4 h / 111 °C

With pyridine; copper(l) iodide; sodium azide; potassium borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 1: Michael addition;
DOI:10.1016/j.bmc.2012.01.008