tert-butyl-4-((2-(5-fluoropyrimidin-2-ylamino)-8-(4-methoxybenzyl)-4,5-dihydropyrazolo[3,4-b]thiazolo[4,5-d]azepin-6(8H)-yl)methyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl-4-((2-(5-fluoropyrimidin-2-ylamino)-8-(4-methoxybenzyl)-4,5-dihydropyrazolo[3,4-b]thiazolo[4,5-d]azepin-6(8H)-yl)methyl)piperidine-1-carboxylate
• CAS No.: 1355994-74-9
• Molecular Formula: C₃₁H₃₇FN₈O₃S
• Molecular Weight: 620.751
• Mol file: 1355994-74-9.mol

Synonyms:tert-butyl-4-((2-(5-fluoropyrimidin-2-ylamino)-8-(4-methoxybenzyl)-4,5-dihydropyrazolo[3,4-b]thiazolo[4,5-d]azepin-6(8H)-yl)methyl)piperidine-1-carboxylate

Chemical Property of tert-butyl-4-((2-(5-fluoropyrimidin-2-ylamino)-8-(4-methoxybenzyl)-4,5-dihydropyrazolo[3,4-b]thiazolo[4,5-d]azepin-6(8H)-yl)methyl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-4-((2-(5-fluoropyrimidin-2-ylamino)-8-(4-methoxybenzyl)-4,5-dihydropyrazolo[3,4-b]thiazolo[4,5-d]azepin-6(8H)-yl)methyl)piperidine-1-carboxylate

There total 7 articles about tert-butyl-4-((2-(5-fluoropyrimidin-2-ylamino)-8-(4-methoxybenzyl)-4,5-dihydropyrazolo[3,4-b]thiazolo[4,5-d]azepin-6(8H)-yl)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

1-(5-fluoropyrimidin-2-yl)thiourea (1322703-83-2) + tert-butyl-4-((5-bromo-2-(4-methoxybenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[3,4-b]azepin-8(2H)-yl)methyl)piperidine-1-carboxylate (1355994-73-8) → tert-butyl-4-((2-(5-fluoropyrimidin-2-ylamino)-8-(4-methoxybenzyl)-4,5-dihydropyrazolo[3,4-b]thiazolo[4,5-d]azepin-6(8H)-yl)methyl)piperidine-1-carboxylate (1355994-74-9)

Guidance literature:

In tert-butyl alcohol; at 100 ℃; for 10h;

Reference yield:

8-benzyl-2-(4-methoxybenzyl)-7,8-dihydropyrazolo[3,4-b]azepin-4(2H)-one (1355994-44-3) → tert-butyl-4-((2-(5-fluoropyrimidin-2-ylamino)-8-(4-methoxybenzyl)-4,5-dihydropyrazolo[3,4-b]thiazolo[4,5-d]azepin-6(8H)-yl)methyl)piperidine-1-carboxylate (1355994-74-9)

Guidance literature:

Multi-step reaction with 5 steps

1: ammonium formate / palladium(II) hydroxide / methanol

2: potassium carbonate; lithium bromide / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C

3: hydrogen; acetic acid / palladium(II) hydroxide / methanol / 10 h / 50 °C

4: phenyltrimethylammonium tribromide / chloroform / 0.33 h / 90 °C

5: tert-butyl alcohol / 10 h / 100 °C

With hydrogen; ammonium formate; phenyltrimethylammonium tribromide; potassium carbonate; acetic acid; lithium bromide; palladium(II) hydroxide; In 1-methyl-pyrrolidin-2-one; methanol; chloroform; tert-butyl alcohol;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl-4-((2-(5-fluoropyrimidin-2-ylamino)-8-(4-methoxybenzyl)-4,5-dihydropyrazolo[3,4-b]thiazolo[4,5-d]azepin-6(8H)-yl)methyl)piperidine-1-carboxylate (1355994-74-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; acetic acid / palladium(II) hydroxide / methanol / 10 h / 50 °C

2: phenyltrimethylammonium tribromide / chloroform / 0.33 h / 90 °C

3: tert-butyl alcohol / 10 h / 100 °C

With hydrogen; phenyltrimethylammonium tribromide; acetic acid; palladium(II) hydroxide; In methanol; chloroform; tert-butyl alcohol;

upstream raw materials:

di-tert-butyl dicarbonate

2-(4-methoxybenzyl)-7,8-dihydropyrazolo[3,4-b]azepin-4(2H)-one

2-(4-methoxybenzyl)-8-(pyridin-4-ylmethyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(2H)-one

tert-butyl-4-((2-(4-methoxybenzyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[3,4-b]azepin-8(2H)-yl)methyl)piperidine-1-carboxylate