Trifluoro-acetic acid (1R,2R,3S)-3-methoxy-2-methyl-5-(toluene-4-sulfonyloxy)-1-((R)-1-{(4R,5R,6S)-2,2,5-trimethyl-6-[(S)-1-(5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-[1,3]dioxan-4-yl}-ethyl)-pentyl ester

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Chemical Name:Trifluoro-acetic acid (1R,2R,3S)-3-methoxy-2-methyl-5-(toluene-4-sulfonyloxy)-1-((R)-1-{(4R,5R,6S)-2,2,5-trimethyl-6-[(S)-1-(5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-[1,3]dioxan-4-yl}-ethyl)-pentyl ester
CAS No.:82849-17-0
Molecular Formula:C₃₃H₄₇F₃O₁₀S
Molecular Weight:692.791
Hs Code.:

Trifluoro-acetic acid (1R,2R,3S)-3-methoxy-2-methyl-5-(toluene-4-sulfonyloxy)-1-((R)-1-{(4R,5R,6S)-2,2,5-trimethyl-6-[(S)-1-(5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-[1,3]dioxan-4-yl}-ethyl)-pentyl ester

Synonyms:Trifluoro-acetic acid (1R,2R,3S)-3-methoxy-2-methyl-5-(toluene-4-sulfonyloxy)-1-((R)-1-{(4R,5R,6S)-2,2,5-trimethyl-6-[(S)-1-(5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-[1,3]dioxan-4-yl}-ethyl)-pentyl ester

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Chemical Property of Trifluoro-acetic acid (1R,2R,3S)-3-methoxy-2-methyl-5-(toluene-4-sulfonyloxy)-1-((R)-1-{(4R,5R,6S)-2,2,5-trimethyl-6-[(S)-1-(5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-[1,3]dioxan-4-yl}-ethyl)-pentyl ester

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Technology Process of Trifluoro-acetic acid (1R,2R,3S)-3-methoxy-2-methyl-5-(toluene-4-sulfonyloxy)-1-((R)-1-{(4R,5R,6S)-2,2,5-trimethyl-6-[(S)-1-(5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-[1,3]dioxan-4-yl}-ethyl)-pentyl ester

There total 12 articles about Trifluoro-acetic acid (1R,2R,3S)-3-methoxy-2-methyl-5-(toluene-4-sulfonyloxy)-1-((R)-1-{(4R,5R,6S)-2,2,5-trimethyl-6-[(S)-1-(5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-[1,3]dioxan-4-yl}-ethyl)-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82849-05-6
(4S,5R,6S,7S)-9-Benzyloxy-5-hydroxy-7-methoxy-4,6-dimethyl-nonan-3-one

: 82849-17-0
Trifluoro-acetic acid (1R,2R,3S)-3-methoxy-2-methyl-5-(toluene-4-sulfonyloxy)-1-((R)-1-{(4R,5R,6S)-2,2,5-trimethyl-6-[(S)-1-(5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-[1,3]dioxan-4-yl}-ethyl)-pentyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 2,6-lutidine / CH₂Cl₂ / 0 °C

2: lithium 1,1,3,3-tetramethyl-1,3-diphenyldisilazide, bis(cyclopentadienyl)zirconium dichloride / tetrahydrofuran / -40 deg C -> -20 deg C

3: diisobutylaluminium hydride / diethyl ether / -78 °C

4: conc. H₂SO₄ / acetone / 0 °C

5: n-Bu₄NF / tetrahydrofuran / 36 h / 40 °C

6: imidazole / tetrahydrofuran

7: Collins-Ratcliffe oxidation

8: tetrahydrofuran / -78 °C

9: 1.) NaBH₄, 2.) hydrogen / 2.) 5percent Pd/C

10: triethylamine / benzene

11: hydrolysis

12: C₅H₅N / CH₂Cl₂ / 48 h / 0 °C

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; sodium tetrahydroborate; zirconocene dichloride; lithium bis(dimethylphenylsilyl)amide; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; diisobutylaluminium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; acetone; benzene;
DOI:10.1021/ja00384a063

Reference yield:

: 82864-88-8
(4S,5R,6R,7S)-9-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-7-methoxy-4,6-dimethyl-nonan-3-one

: 82849-17-0
Trifluoro-acetic acid (1R,2R,3S)-3-methoxy-2-methyl-5-(toluene-4-sulfonyloxy)-1-((R)-1-{(4R,5R,6S)-2,2,5-trimethyl-6-[(S)-1-(5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-[1,3]dioxan-4-yl}-ethyl)-pentyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: lithium 1,1,3,3-tetramethyl-1,3-diphenyldisilazide, bis(cyclopentadienyl)zirconium dichloride / tetrahydrofuran / -40 deg C -> -20 deg C

2: diisobutylaluminium hydride / diethyl ether / -78 °C

3: conc. H₂SO₄ / acetone / 0 °C

4: n-Bu₄NF / tetrahydrofuran / 36 h / 40 °C

5: imidazole / tetrahydrofuran

6: Collins-Ratcliffe oxidation

7: tetrahydrofuran / -78 °C

8: 1.) NaBH₄, 2.) hydrogen / 2.) 5percent Pd/C

9: triethylamine / benzene

10: hydrolysis

11: C₅H₅N / CH₂Cl₂ / 48 h / 0 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; zirconocene dichloride; lithium bis(dimethylphenylsilyl)amide; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen; diisobutylaluminium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; acetone; benzene;
DOI:10.1021/ja00384a063

Reference yield:

: 82849-10-3
(2S,3R,4S,5S)-7-Benzyloxy-2-[(4S,5R,6S)-6-((S)-2-hydroxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-5-methoxy-4-methyl-heptan-3-ol

: 82849-17-0
Trifluoro-acetic acid (1R,2R,3S)-3-methoxy-2-methyl-5-(toluene-4-sulfonyloxy)-1-((R)-1-{(4R,5R,6S)-2,2,5-trimethyl-6-[(S)-1-(5-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-ethyl]-[1,3]dioxan-4-yl}-ethyl)-pentyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole / tetrahydrofuran

2: Collins-Ratcliffe oxidation

3: tetrahydrofuran / -78 °C

4: 1.) NaBH₄, 2.) hydrogen / 2.) 5percent Pd/C

5: triethylamine / benzene

6: hydrolysis

7: C₅H₅N / CH₂Cl₂ / 48 h / 0 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ja00384a063