6-chloro-3-[1-(3-chloro-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one

Base Information

• Chemical Name: 6-chloro-3-[1-(3-chloro-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
• CAS No.: 860798-06-7
• Molecular Formula: C₁₅H₉Cl₂NO
• Molecular Weight: 290.149

Synonyms:6-chloro-3-[1-(3-chloro-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one

Chemical Property of 6-chloro-3-[1-(3-chloro-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one

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Technology Process of 6-chloro-3-[1-(3-chloro-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one

There total 3 articles about 6-chloro-3-[1-(3-chloro-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

rac-(3'S,4'R)-1'-benzyl-6-chloro-4'-(3-chloro-phenyl)-1H-spiro[indole-3,3'-pyrrolidin]-2-one → 6-chloro-3-[1-(3-chloro-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one (860798-06-7)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester; In dichloromethane; at 5 - 20 ℃; for 19h;

DOI:10.1021/acs.jmedchem.6b00900

Reference yield:

6-chloro-2-oxindole (56341-37-8) + m-Chlorobenzaldehyde (587-04-2) → 6-chloro-3-[1-(3-chloro-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one (860798-06-7) + Z-6-chloro-3-[1-(3-chlorophenyl)-methylidene]-1,3-dihydro-indol-2-one

Guidance literature:

With pyrrolidine; In methanol; at 70 ℃; for 3h;

Reference yield:

→ 6-chloro-3-[1-(3-chloro-phenyl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one (860798-06-7)

Guidance literature:

upstream raw materials:

6-chloro-2-oxindole

m-Chlorobenzaldehyde

Downstream raw materials:

E/Z-6-chloro-3-(3-chloro-benzylidene)-2-oxo-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

(1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2'-(3-methylbutyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide

(1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-2'-(2,2-dimethylpropyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide

(1''R,2''S,2'R,3'R,3S,4'R)-6-chloro-4'-(3-chlorophenyl)-1'-(2-hydroxy-1,2-diphenylethyl)-2'-propyl-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide

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