5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylic acid

Base Information

Chemical Name:5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylic acid
CAS No.:943780-21-0
Molecular Formula:C₂₁H₁₉N₅O₂S₂
Molecular Weight:437.546
Hs Code.:

Synonyms:5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylic acid

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Chemical Property of 5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylic acid

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Technology Process of 5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylic acid

There total 10 articles about 5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 943780-20-9
ethyl 5-(4-(((9H-fluoren-9-yl)methoxy)carbonylamino)phenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylate

: 943780-21-0
5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylic acid

Guidance literature:: ethyl 5-(4-(((9H-fluoren-9-yl)methoxy)carbonylamino)phenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylate; With lithium hydroxide; In 1,4-dioxane; water; at 20 - 60 ℃; for 0.416667h;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

: 55793-14-1
4-methyl-3-oxo-pentanal; sodium enolate

: 943780-21-0
5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: water / 0.17 h / 20 °C

1.2: 2 h / Heating / reflux

1.3: pH 4

2.1: tetrabutylammomium bromide; phosphorus pentoxide / toluene / 5 h / Heating / reflux

3.1: ammonia / ethanol / 20 h / 130 °C

4.1: toluene / 3 h / Heating / reflux

5.1: acetic acid / 0.5 h / 140 °C

6.1: lithium hydroxide / 1,4-dioxane; water / 0.42 h / 20 - 60 °C

With lithium hydroxide; tetrabutylammomium bromide; ammonia; phosphorus pentoxide; In 1,4-dioxane; ethanol; water; acetic acid; toluene;

Reference yield:

: 563-80-4
3-methyl-butan-2-one

: 943780-21-0
5-(4-aminophenylthio)-4-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium / diethyl ether / 0 - 20 °C

2.1: water / 0.17 h / 20 °C

2.2: 2 h / Heating / reflux

2.3: pH 4

3.1: tetrabutylammomium bromide; phosphorus pentoxide / toluene / 5 h / Heating / reflux

4.1: ammonia / ethanol / 20 h / 130 °C

5.1: toluene / 3 h / Heating / reflux

6.1: acetic acid / 0.5 h / 140 °C

7.1: lithium hydroxide / 1,4-dioxane; water / 0.42 h / 20 - 60 °C

With lithium hydroxide; tetrabutylammomium bromide; ammonia; sodium; phosphorus pentoxide; In 1,4-dioxane; diethyl ether; ethanol; water; acetic acid; toluene;