ethyl 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoate

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Chemical Name:ethyl 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoate
CAS No.:871657-02-2
Molecular Formula:C₂₄H₂₅N₃O₆
Molecular Weight:451.479
Hs Code.:

Synonyms:ethyl 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoate

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Chemical Property of ethyl 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoate

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Technology Process of ethyl 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoate

There total 8 articles about ethyl 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871656-68-7
3-hydroxy-5-{[(1S)-2-hydroxy-1-methylethyl]oxy}-N-(5-methylpyrazin-2-yl)benzamide

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 871657-02-2
ethyl 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoate

Guidance literature:: With caesium carbonate; In ISOPROPYLAMIDE; at 130 ℃; for 72h;

Reference yield:

: 851885-41-1
3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]benzoic acid

: 871657-02-2
ethyl 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 - 16 h / 0 - 20 °C

2.1: pyridine / N,N-dimethyl-formamide / dichloromethane / 24 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 20 h / 20 °C

4.1: trimethylsilyl iodide / acetonitrile / 24 h

4.2: 0.17 h

5.1: caesium carbonate / ISOPROPYLAMIDE / 72 h / 130 °C

With pyridine; oxalyl dichloride; trimethylsilyl iodide; hydrogen; caesium carbonate; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; acetonitrile;

Reference yield:

: C₁₈H₁₉ClO₄

: 871657-02-2
ethyl 4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(5-methylpyrazin-2-yl)amino]carbonyl}phenoxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / N,N-dimethyl-formamide / dichloromethane / 24 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethanol / 20 h / 20 °C

3.1: trimethylsilyl iodide / acetonitrile / 24 h

3.2: 0.17 h

4.1: caesium carbonate / ISOPROPYLAMIDE / 72 h / 130 °C

With pyridine; trimethylsilyl iodide; hydrogen; caesium carbonate; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; acetonitrile;