tert butyl (R)-4-((3aS,6aS)-5-(2,2,2-trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-1-(2,4,5-trifluorophenyl)-4-oxybutan-2-ylcarbamate

Base Information

Chemical Name:tert butyl (R)-4-((3aS,6aS)-5-(2,2,2-trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-1-(2,4,5-trifluorophenyl)-4-oxybutan-2-ylcarbamate
CAS No.:1350553-74-0
Molecular Formula:C₂₃H₂₇F₆N₃O₄
Molecular Weight:523.475
Hs Code.:

Synonyms:tert butyl (R)-4-((3aS,6aS)-5-(2,2,2-trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-1-(2,4,5-trifluorophenyl)-4-oxybutan-2-ylcarbamate

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Chemical Property of tert butyl (R)-4-((3aS,6aS)-5-(2,2,2-trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-1-(2,4,5-trifluorophenyl)-4-oxybutan-2-ylcarbamate

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Technology Process of tert butyl (R)-4-((3aS,6aS)-5-(2,2,2-trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-1-(2,4,5-trifluorophenyl)-4-oxybutan-2-ylcarbamate

There total 3 articles about tert butyl (R)-4-((3aS,6aS)-5-(2,2,2-trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-1-(2,4,5-trifluorophenyl)-4-oxybutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2,2,2-trifluoro-1-((3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)ethanone

: 486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

: 1350553-74-0
tert butyl (R)-4-((3aS,6aS)-5-(2,2,2-trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-1-(2,4,5-trifluorophenyl)-4-oxybutan-2-ylcarbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1-[(3aS,6aS)-1-[(1R)-1-phenylethyl]-2,3,3a,4,6,6a-hexahydropyrrolo[3,4-b]pyrrole-5-yl]-2,2,2-trifluoroethanone

: 1350553-74-0
tert butyl (R)-4-((3aS,6aS)-5-(2,2,2-trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-1-(2,4,5-trifluorophenyl)-4-oxybutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium(II) hydroxide / methanol / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 4 h / 20 °C

With hydrogen; palladium(II) hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;

Reference yield:

: 370880-12-9
(3aS,6aS)-1-[(1R)-1-phenylethyl]-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[3,4-b]pyrrole

: 1350553-74-0
tert butyl (R)-4-((3aS,6aS)-5-(2,2,2-trifluoroacetyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)-1-(2,4,5-trifluorophenyl)-4-oxybutan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 20 °C / Cooling with ice

2: hydrogen; palladium(II) hydroxide / methanol / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 4 h / 20 °C

With dmap; hydrogen; palladium(II) hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;