1,2-Dichloro-4-(difluoromethyl)benzene

Base Information

Chemical Name:1,2-Dichloro-4-(difluoromethyl)benzene
CAS No.:52126-13-3
Molecular Formula:C₇H₄Cl₂F₂
Molecular Weight:197.012
Hs Code.:
DSSTox Substance ID:DTXSID701283234
Nikkaji Number:J2.999.899J

Synonyms:1,2-Dichloro-4-(difluoromethyl)benzene;52126-13-3;starbld0022390;SCHEMBL10680633;DTXSID701283234;MFCD14698569;SY265658

Suppliers and Price of 1,2-Dichloro-4-(difluoromethyl)benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,2-Dichloro-4-(difluoromethyl)benzene

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:195.9658118
Heavy Atom Count:11
Complexity:130

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1C(F)F)Cl)Cl

Technology Process of 1,2-Dichloro-4-(difluoromethyl)benzene

There total 6 articles about 1,2-Dichloro-4-(difluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1511-62-2
bromodifluoromethane

: 151169-75-4
3,4-dichlophenylboronic acid

: 52126-13-3
1,2-dichloro-4-(difluoromethyl)benzene

Guidance literature:: With dmap; dibromobis(triphenylphosphine)nickel(II); potassium carbonate; In tetrahydrofuran; at 80 ℃; for 17h; Schlenk technique; Inert atmosphere; Sealed tube;
DOI:10.1002/cjoc.201700624

Reference yield:

: 56072-00-5
2-(3,4-dichlorophenyl)-2,2-difluoroacetic acid

: 52126-13-3
1,2-dichloro-4-(difluoromethyl)benzene

Guidance literature:: With potassium fluoride; In N,N-dimethyl-formamide; at 170 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol202289z

Reference yield:

: 20555-91-3
3,4-dichloroiodobenzene

: 52126-13-3
1,2-dichloro-4-(difluoromethyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; potassium fluoride / dimethyl sulfoxide / 15 h / 60 °C / Inert atmosphere

2: water; potassium carbonate / methanol / 2 h / 25 °C / Inert atmosphere

3: potassium fluoride / N,N-dimethyl-formamide / 12 h / 170 °C / Inert atmosphere

With potassium fluoride; copper(l) iodide; water; potassium carbonate; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ol202289z