1-(2-methoxyquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone

Base Information

Chemical Name:1-(2-methoxyquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone
CAS No.:796854-55-2
Molecular Formula:C₂₄H₂₆N₄O₆S
Molecular Weight:498.56
Hs Code.:

Synonyms:1-(2-methoxyquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone

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Chemical Property of 1-(2-methoxyquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone

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Technology Process of 1-(2-methoxyquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone

There total 1 articles about 1-(2-methoxyquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 108-24-7
acetic anhydride

: 67-68-5,8070-53-9
dimethyl sulfoxide

: 796854-51-8
2-[5-(4-methanesulfonyl-piperazin-1-yl-methyl)-2-nitrophenyl]-1-(2-methoxyquinolin-3-yl)-ethanol

: 796854-55-2
1-(2-methoxyquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone

: 2-methoxy-3-{2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)-1-[(methylthio)methoxy]ethyl}quinoline

: 1-(2-methoxyquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethyl acetate

Guidance literature:: In Isopropyl acetate; at 80 ℃; for 2h;
DOI:10.1021/jo048843m DOI:10.1021/jo0480545

Reference yield: 90.0%

: 796854-55-2
1-(2-methoxyquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone

: 2-methoxy-3-(5-methyl-1H-indol-2-yl)quinoline

: 2-(2-amino-5-methylphenyl)-1-(2-methoxyquinolin-3-yl)ethanol

: 796854-61-0
2-methoxy-3-(5-{[4-(methylsulfonyl)-1-piperazinyl]-methyl}-1H-indol-2-yl)-quinoline

: 2-(2-amino-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-1-(2-methoxyquinolin-3-yl)ethanol

Guidance literature:: With hydrogen; Raney nickel 2800; In tetrahydrofuran; at 65 ℃; for 7.5h; under 2068.59 Torr;
DOI:10.1021/jo0480545

Reference yield:

: 796854-55-2
1-(2-methoxyquinolin-3-yl)-2-(5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-2-nitrophenyl)ethanone

: 796854-61-0
2-methoxy-3-(5-{[4-(methylsulfonyl)-1-piperazinyl]-methyl}-1H-indol-2-yl)-quinoline

: 2-(2-methoxyquinolin-3-yl)-5-{[4-(methylsulfonyl)-1-piperazin-1-yl]methyl}-1H-indol-1-ol

: 2-(2-amino-5-{[4-(methylsulfonyl)piperazin-1-yl]methyl}phenyl)-1-(2-methoxyquinolin-3-yl)ethanol

Guidance literature:: With hydrogen; Raney Ni 2800 (H₂O); In tetrahydrofuran; at 65 ℃; for 6h; under 3102.89 Torr; Further Variations:; Catalysts; Pressures; Product distribution;
DOI:10.1021/jo048843m