4,4,4-Trifluoro-1-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-but-2-en-1-one

Base Information

• Chemical Name: 4,4,4-Trifluoro-1-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-but-2-en-1-one
• CAS No.: 159429-76-2
• Molecular Formula: C₁₂H₈F₆OS
• Molecular Weight: 314.251

Synonyms:4,4,4-Trifluoro-1-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-but-2-en-1-one

Chemical Property of 4,4,4-Trifluoro-1-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-but-2-en-1-one

Chemical Property:

Purity/Quality:

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Technology Process of 4,4,4-Trifluoro-1-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-but-2-en-1-one

There total 2 articles about 4,4,4-Trifluoro-1-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-but-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4,4-Trifluoro-3-hydroxy-1-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-butan-1-one → 4,4,4-Trifluoro-1-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-but-2-en-1-one (159429-76-2)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In dichloromethane; at 0 ℃;

DOI:10.1021/jm00049a005

Reference yield:

Trimethyl-[1-(4-methylsulfanyl-phenyl)-vinyloxy]-silane (159429-74-0) → 4,4,4-Trifluoro-1-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-but-2-en-1-one (159429-76-2)

Guidance literature:

Multi-step reaction with 2 steps

1: titanium(IV) chloride / CH₂Cl₂

2: trifluoroacetic anhydride, pyridine / CH₂Cl₂ / 0 °C

With pyridine; titanium tetrachloride; trifluoroacetic anhydride; In dichloromethane;

DOI:10.1021/jm00049a005

Reference yield:

((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane (58518-77-7) + 4,4,4-Trifluoro-1-(4-methylsulfanyl-phenyl)-3-trifluoromethyl-but-2-en-1-one (159429-76-2) → 1-(4-Fluoro-phenyl)-5-(4-methylsulfanyl-phenyl)-3,3-bis-trifluoromethyl-pentane-1,5-dione (159429-80-8)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -78 ℃;

DOI:10.1021/jm00049a005

upstream raw materials:

Trimethyl-[1-(4-methylsulfanyl-phenyl)-vinyloxy]-silane

Downstream raw materials:

1-(4-Fluoro-phenyl)-5-(4-methylsulfanyl-phenyl)-3,3-bis-trifluoromethyl-pentane-1,5-dione

C₂₀H₁₅F₇S

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