tert-butyl (1S,2R)-2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate

Base Information

Chemical Name:tert-butyl (1S,2R)-2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate
CAS No.:1350707-65-1
Molecular Formula:C₁₆H₁₉ClO₄
Molecular Weight:310.777
Hs Code.:

Synonyms:tert-butyl (1S,2R)-2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate

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Chemical Property of tert-butyl (1S,2R)-2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate

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Technology Process of tert-butyl (1S,2R)-2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate

There total 4 articles about tert-butyl (1S,2R)-2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1005415-72-4
tert-butyl 2-diazo-2-(3-methoxyphenyl)acetate

: 683-51-2
2-chloro-2-propenal

: 1350707-65-1
tert-butyl (1S,2R)-2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate

: tert-butyl 2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate

Guidance literature:: With CHF₃O₃S*C₃₁H₃₂BNO; at -45 ℃; for 1h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/jacs.1c03211

Reference yield: 87.0%

: 1005415-72-4
tert-butyl 2-diazo-2-(3-methoxyphenyl)acetate

: 683-51-2
2-chloro-2-propenal

: 1350707-65-1
tert-butyl (1S,2R)-2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate

: tert-butyl 2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate

Guidance literature:: With CHF₃O₃S*C₃₁H₃₂BNO; In propiononitrile; at -45 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja209270e

Reference yield:

: 62381-21-9
tert-butyl-α-(3-methoxyphenyl)acetate

: 1350707-65-1
tert-butyl (1S,2R)-2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate

: tert-butyl 2-chloro-2-formyl-1-(3-methoxyphenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 0 - 20 °C / Inert atmosphere

2: CHF₃O₃S*C₃₁H₃₂BNO / 1 h / -45 °C / Inert atmosphere

With CHF₃O₃S*C₃₁H₃₂BNO; 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;
DOI:10.1021/jacs.1c03211