ethyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(isopropylamino)benzoate

Base Information

Chemical Name:ethyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(isopropylamino)benzoate
CAS No.:1445791-23-0
Molecular Formula:C₂₈H₃₀N₆O₅
Molecular Weight:530.583
Hs Code.:

Synonyms:ethyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(isopropylamino)benzoate

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Chemical Property of ethyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(isopropylamino)benzoate

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Technology Process of ethyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(isopropylamino)benzoate

There total 5 articles about ethyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(isopropylamino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445792-05-1
C₁₂H₁₈N₂O₂

: 1374867-83-0
4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide

: 1445791-23-0
ethyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(isopropylamino)benzoate

Guidance literature:: With acetic acid; at 50 ℃; for 18h;

Reference yield:

: 1445791-21-8
ethyl 3-(isopropylamino)-5-nitrobenzoate

: 1445791-23-0
ethyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(isopropylamino)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; 5%-palladium/activated carbon / methanol / 2 h / 760.05 Torr

2: acetic acid / 18 h / 50 °C

With 5%-palladium/activated carbon; hydrogen; acetic acid; In methanol;

Reference yield:

: 690260-94-7
ethyl 3-bromo-5-nitrobenzoate

: 1445791-23-0
ethyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(isopropylamino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; palladium diacetate; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 140 °C / Microwave irradiation

2: hydrogen; 5%-palladium/activated carbon / methanol / 2 h / 760.05 Torr

3: acetic acid / 18 h / 50 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; palladium diacetate; caesium carbonate; acetic acid; In 1,4-dioxane; methanol;