(R)-10-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-propyl]-9-oxa-1,5-dithia-spiro[5.5]undecan-8-one

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Chemical Name:(R)-10-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-propyl]-9-oxa-1,5-dithia-spiro[5.5]undecan-8-one
CAS No.:88559-63-1
Molecular Formula:C₂₇H₃₆O₃S₂Si
Molecular Weight:500.799
Hs Code.:

Synonyms:(R)-10-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-propyl]-9-oxa-1,5-dithia-spiro[5.5]undecan-8-one

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Chemical Property of (R)-10-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-propyl]-9-oxa-1,5-dithia-spiro[5.5]undecan-8-one

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Technology Process of (R)-10-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-propyl]-9-oxa-1,5-dithia-spiro[5.5]undecan-8-one

There total 7 articles about (R)-10-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-propyl]-9-oxa-1,5-dithia-spiro[5.5]undecan-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 88559-62-0,96479-70-8
(S)-10-((S)-2-Hydroxy-propyl)-9-oxa-1,5-dithia-spiro[5.5]undecan-8-one

: 58479-61-1
tert-butylchlorodiphenylsilane

: 88559-63-1
(R)-10-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-propyl]-9-oxa-1,5-dithia-spiro[5.5]undecan-8-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0040-4039(00)94299-0

Reference yield:

: 88559-75-5
5-Methoxymethoxy-3-oxo-hexanoic acid ethyl ester

: 88559-63-1
(R)-10-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-propyl]-9-oxa-1,5-dithia-spiro[5.5]undecan-8-one

Guidance literature:: Multi-step reaction with 7 steps

1: BF₃*Et₂O

2: 94 percent / LDA / tetrahydrofuran / -78 °C

3: CSA / CH₂Cl₂; methanol / Ambient temperature

4: NBS/AgNO₃/Na₂CO₃ / H₂O; acetonitrile / 0 °C

5: 96 percent / K-Selectride / tetrahydrofuran / -78 °C

6: 80 percent / BF₃*Et₂O / CH₂Cl₂ / -40 °C

7: 81 percent / imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; N-Bromosuccinimide; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; sodium carbonate; potassium tri-sec-butyl-borohydride; silver nitrate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)94299-0

Reference yield:

: 88559-57-3
9-Methyl-8-oxa-1,4-dithia-spiro[4.5]decan-7-one

: 88559-63-1
(R)-10-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-propyl]-9-oxa-1,5-dithia-spiro[5.5]undecan-8-one

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / LDA / tetrahydrofuran / -78 °C

2: CSA / CH₂Cl₂; methanol / Ambient temperature

3: NBS/AgNO₃/Na₂CO₃ / H₂O; acetonitrile / 0 °C

4: 96 percent / K-Selectride / tetrahydrofuran / -78 °C

5: 80 percent / BF₃*Et₂O / CH₂Cl₂ / -40 °C

6: 81 percent / imidazole / dimethylformamide / Ambient temperature

With 1H-imidazole; N-Bromosuccinimide; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; sodium carbonate; potassium tri-sec-butyl-borohydride; silver nitrate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)94299-0